Dearomative 1,2‐(Deutero)Hydrotrifluoromethylation of Chromium‐Bound Arenes
Cheng‐Jie Wu,
Xu Jiang,
Jia‐Yi Qiu
et al.
Abstract:Dearomative trifluoromethylation of arenes provides an ideal method for constructing CF3‐containing three‐dimensional architectures which are of increasing interest in drug discovery. However, such transformation is rare and challenging because of the inherently low reactivity of arene π‐systems and selectivity issues. Herein, we disclose a general dearomative 1,2‐hydrotrifluoromethylation of (hetero)arenes utilizing activation by temporary π‐complexation to chromium, thus affording convenient access to 1,3‐cy… Show more
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