Dearomatized white spirit inhalation exposure causes long-lasting neurophysiological changes in rats

Lund, Søren Peter; Simonsen, Leif; Hass, Ulla; Ladefoged, Ole; Lam, Henrik Rye; Østergaard, Grete

doi:10.1016/0892-0362(95)02014-4

Cited by 25 publications

(19 citation statements)

References 45 publications

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“…The increase in cytosolic calcium concentration suggests that prenatal exposure to white spirit causes effects which last even at birth after cessation of exposure (table 2), which is in accordance with previous experiments with organic solvents (Hass et al 1995;Gospe et al 1996, Korbo et al 1996Lund et al;Hass et al 1997;Gospe & Zhou 1998). The mechanisms behind the increased calcium concen- Table 3A.…”

Section: Discussionsupporting

confidence: 87%

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The Effect of in vitro Exposure to White Spirit on [Ca²⁺_i] in Synaptosomes from Rats Exposed Prenatally to White Spirit

Edelfors

Hass²,

Ravn-Jonsen

1999

Pharmacology & Toxicology

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Female rats were exposed to white spirit (400 and 800 ppm for 6 hr/day) at day 7-20 during pregnancy. Thirtyfive days after birth all female offspring were sacrificed, the brains removed, and the synaptosomal fractions prepared for in vitro studies. The cytosolic calcium concentration was measured using the FURA-2 technique. The results show that cytosolic calcium was increased in synaptosomes from rats exposed to white spirit prenatally compared to synaptosomes from unexposed rats. When synaptosomes were exposed to white spirit in vitro, the cytosolic calcium concentration changes were identical in all groups of rats. The membrane leakage measured as FURA-2 leakage from the synaptosomes identical in all three groups of animals. The results suggest that prenatal exposure to white spirit induces long-lasting and possibly irreversible changes in calcium homeostasis in the rat nervous system.

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Section: Discussionsupporting

confidence: 87%

“…Behavioural, neurophysiological, morphological and biochemical changes have been seen up to 6 months after the cessation of the exposure (Hass et ul. 1995;Lund et al 1996;Korbo et ul. 1996;Hass et ul.…”

Section: Discussionmentioning

confidence: 99%

The Effect of in vitro Exposure to White Spirit on [Ca²⁺_i] in Synaptosomes from Rats Exposed Prenatally to White Spirit

Edelfors

Hass²,

Ravn-Jonsen

1999

Pharmacology & Toxicology

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“…Exposure to ethyl benzene in rats resulted in an increase in the threshold for the compound action potential by up to 30 dB in a large frequency range (1-24 kHz), due to outer hair cell loss (21). White spirit exposure also led to a dose-dependent increase in the amplitude of the auditory brainstem response of the same strain of animals (22). No data on the ototoxicity of isolated exposure to ethyl acetate and butyl acetate are yet available.…”

Section: Discussionmentioning

confidence: 99%

Hearing loss among workers exposed to moderate concentrations of solvents

Śliwińska-Kowalska¹,

Zamysłowska-Szmytke²,

Szymczak³

et al. 2001

Scand J Work Environ Health

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“…Glomerulonephritis has been described in humans in association with organic solvent exposure (Daniell et al, 1988). Neurologic effects, including changes in the brain content of neurotransmitters and in sensory evoked potentials, and decreases in motor activity during dark periods were seen in rats exposed to inhaled Stoddard solvent, although without accompanying histopathological changes (Lam et al, 1994;Lund et al, 1996;Ostergaard et al, 1993).…”

mentioning

confidence: 98%

Development of α_2u-Globulin Nephropathy and Adrenal Medullary Pheochromocytomas in Male Rats Following Exposure to Stoddard Solvent IIC

Doi

Peckham

Chou

et al. 2004

Inhalation Toxicology

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Stoddard solvent IIC is widely used as a solvent in paints and varnishes, and for dry cleaning and other grease removal applications. Because concern exists regarding the long-term effects of occupational exposure in industrial settings, the toxicity and carcinogenicity of Stoddard solvent IIC were evaluated in male and female F344/N rats and B6C3F1 mice. Rats and mice were exposed to 0, 138, 275, 550, 1100, or 2200 mg/m3 Stoddard solvent IIC by whole-body inhalation for 3 mo, and to 0, 138 (male rats), 550, 1100, or 2200 (female rats and male and female mice) mg/m3 for 2 yr. The kidney, liver, and adrenal medulla were targets of Stoddard solvent IIC toxicity in rats. After 3 mo of exposure, male rats developed lesions characteristic of alpha2u-globulin nephropathy. Male and female rats displayed increased liver weights and/or clinical pathology changes suggestive of hepatic injury, although no accompanying histopathologic changes were observed. After 2 yr, increased incidences of adrenal medullary pheochromocytomas provided some evidence of carcinogenicity in male rats. Renal tubule adenomas were slightly increased in male rats after 2 yr, and may have been related to exposure. In mice, there was no chemical-related toxicity after 3 mo, with the exception of increased liver weights in male mice exposed to 2200 mg/m3. After 2 yr, the incidences of hepatocellular adenomas were increased in female mice exposed to 2200 mg/m3; however, these increases were marginal and associated with increases in body weight. There was no evidence of Stoddard solvent IIC carcinogenicity in female rats or male mice. In summary, inhalation exposures of Stoddard solvent IIC resulted in renal toxicity and adrenal medullary pheochromocytomas in male rats. The liver also appeared to be a site of toxicity in male and female rats and mice.

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Dearomatized white spirit inhalation exposure causes long-lasting neurophysiological changes in rats

Cited by 25 publications

References 45 publications

The Effect of in vitro Exposure to White Spirit on [Ca²⁺_i] in Synaptosomes from Rats Exposed Prenatally to White Spirit

The Effect of in vitro Exposure to White Spirit on [Ca²⁺_i] in Synaptosomes from Rats Exposed Prenatally to White Spirit

Hearing loss among workers exposed to moderate concentrations of solvents

Development of α_2u-Globulin Nephropathy and Adrenal Medullary Pheochromocytomas in Male Rats Following Exposure to Stoddard Solvent IIC

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Dearomatized white spirit inhalation exposure causes long-lasting neurophysiological changes in rats

Cited by 25 publications

References 45 publications

The Effect of in vitro Exposure to White Spirit on [Ca2+i] in Synaptosomes from Rats Exposed Prenatally to White Spirit

The Effect of in vitro Exposure to White Spirit on [Ca2+i] in Synaptosomes from Rats Exposed Prenatally to White Spirit

Hearing loss among workers exposed to moderate concentrations of solvents

Development of α2u-Globulin Nephropathy and Adrenal Medullary Pheochromocytomas in Male Rats Following Exposure to Stoddard Solvent IIC

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The Effect of in vitro Exposure to White Spirit on [Ca²⁺_i] in Synaptosomes from Rats Exposed Prenatally to White Spirit

The Effect of in vitro Exposure to White Spirit on [Ca²⁺_i] in Synaptosomes from Rats Exposed Prenatally to White Spirit

Development of α_2u-Globulin Nephropathy and Adrenal Medullary Pheochromocytomas in Male Rats Following Exposure to Stoddard Solvent IIC