Death After Poison Ivy Smoke Inhalation

Woolery, Samantha; Willner, Joseph H.; Prahlow, Joseph A.; Douglas, Elizabeth

doi:10.1097/paf.0000000000000777

Cited by 3 publications

(2 citation statements)

References 13 publications

(50 reference statements)

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“…For example, smoke from fires that burn through poison oak, poison ivy, and poison sumac may contain traces of the irritant urushiol that induces a delayed-type hypersensitivity response upon inhalation. Such exposure can cause severe respiratory distress [41]. Whether wildfire smoke containing allergenic particles could directly induce respiratory allergies is not clear [2].…”

Section: Particulate Mattermentioning

confidence: 99%

“Air That Once Was Breath” Part 1: Wildfire-Smoke-Induced Mechanisms of Airway Inflammation – “Climate Change, Allergy and Immunology” Special IAAI Article Collection: Collegium Internationale Allergologicum Update 2023

Bowman,

Schmidt,

Sanghar

et al. 2024

Int Arch Allergy Immunol

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Background: Wildfires are a global concern due to their wide-ranging environmental, economic, and public health impacts. Climate change contributes to an increase in the frequency and intensity of wildfires making smoke exposure a more significant and recurring health concern for individuals with airway diseases. Some of the most prominent effects of wildfire smoke exposure are asthma exacerbations and allergic airway sensitization. Likely due to the delayed recognition of its health impacts in comparison with cigarette smoke and industrial or traffic-related air pollution, research on the composition, the mechanisms of toxicity, and the cellular/molecular pathways involved is poor or non-existent. Summary: This review discusses potential underlying pathological mechanisms of wildfire-smoke-related allergic airway disease and asthma. We focused on major gaps in understanding the role of wildfire smoke composition in the development of airway disease and the known and potential mechanisms involving cellular and molecular players of oxidative injury at the epithelial barrier in airway inflammation. We examine how PM2.5, VOCs, O3, endotoxin, microbes, and toxic gases may affect oxidative stress and inflammation in the respiratory mucosal barrier. We discuss the role of AhR in mediating smoke’s effects in alarmin release and IL-17A production and how glucocorticoid responsiveness may be impaired by IL-17A-induced signaling and epigenetic changes leading to steroid-resistant severe airway inflammation. Key Message: Effective mitigation of wildfire-smoke-related respiratory health effects would require comprehensive research efforts aimed at a better understanding of the immune regulatory effects of wildfire smoke in respiratory health and disease.

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Section: Particulate Mattermentioning

confidence: 99%

“Air That Once Was Breath” Part 1: Wildfire-Smoke-Induced Mechanisms of Airway Inflammation – “Climate Change, Allergy and Immunology” Special IAAI Article Collection: Collegium Internationale Allergologicum Update 2023

Bowman,

Schmidt,

Sanghar

et al. 2024

Int Arch Allergy Immunol

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“…Gene expression analysis can also be used to study the regulation of metabolic pathways and identify the genes responsible for the production of specific metabolites [ 128 , 129 ]. Some plants contain cyanide or other poisons [ 130 , 131 , 132 , 133 , 134 , 135 , 136 , 137 , 138 , 139 , 140 , 141 , 142 , 143 , 144 , 145 , 146 , 147 ]. Machine learning-based classification algorithms can be used to classify cells of different plant species based on their metabolic profiles and predict the potential production of harmful metabolites, such as allelochemicals and cyanide.…”

Section: Does Data Science Can Help In Studying Plant Metabolites?mentioning

confidence: 99%

Data Science and Plant Metabolomics

Kisiel

Krzemińska²,

Cembrowska-Lech

et al. 2023

Metabolites

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The study of plant metabolism is one of the most complex tasks, mainly due to the huge amount and structural diversity of metabolites, as well as the fact that they react to changes in the environment and ultimately influence each other. Metabolic profiling is most often carried out using tools that include mass spectrometry (MS), which is one of the most powerful analytical methods. All this means that even when analyzing a single sample, we can obtain thousands of data. Data science has the potential to revolutionize our understanding of plant metabolism. This review demonstrates that machine learning, network analysis, and statistical modeling are some techniques being used to analyze large quantities of complex data that provide insights into plant development, growth, and how they interact with their environment. These findings could be key to improving crop yields, developing new forms of plant biotechnology, and understanding the relationship between plants and microbes. It is also necessary to consider the constraints that come with data science such as quality and availability of data, model complexity, and the need for deep knowledge of the subject in order to achieve reliable outcomes.

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Vasopressors/sodium-bicarbonate

2023

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Death After Poison Ivy Smoke Inhalation

Cited by 3 publications

References 13 publications

“Air That Once Was Breath” Part 1: Wildfire-Smoke-Induced Mechanisms of Airway Inflammation – “Climate Change, Allergy and Immunology” Special IAAI Article Collection: Collegium Internationale Allergologicum Update 2023

“Air That Once Was Breath” Part 1: Wildfire-Smoke-Induced Mechanisms of Airway Inflammation – “Climate Change, Allergy and Immunology” Special IAAI Article Collection: Collegium Internationale Allergologicum Update 2023

Data Science and Plant Metabolomics

Vasopressors/sodium-bicarbonate

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