Death and replacement of uterine epithelial cells during oil-induced deciduoma development in the mouse

Andrade, Carlos Rogério; Abrahamsohn, Paulo Alexandre; Godinho, Fábio; Samuel, Edmilson; Zorn, Telma Maria Tenório

doi:10.1002/(sici)1097-0185(199603)244:3<316::aid-ar4>3.0.co;2-w

Cited by 9 publications

(6 citation statements)

References 28 publications

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“…106 This response elicits the formation of a deciduomata that is very similar (albeit not identical 107 ) to true decidua. Extensive observations based on this model have confirmed that the pseudo-decidual reaction is followed by the involution of the anti-mesometrial region 108 and preceded by the degradation of the luminal epithelium (in the rat, 109 in the mouse 110,111 ). Epithelial cells in the antimesometrial zone seem to detach progressively from the basal lamina and show clear signs of degradation (condensation and margination of the nuclear chromatin and dilation of the endoplasmic reticulum) which resemble those detected during normal implantation.…”

Section: Mechanisms Of Cell Death In the Uterusmentioning

confidence: 72%

“…Epithelial cells in the antimesometrial zone seem to detach progressively from the basal lamina and show clear signs of degradation (condensation and margination of the nuclear chromatin and dilation of the endoplasmic reticulum) which resemble those detected during normal implantation. 111 Recent studies based on the visualization of nucleosomal DNA fragmentation support this concept. 112 A second line of evidence pointing towards the existence of an innate cell death program activated around the implantation site in that the removal of the epithelial cells bordering the mesometrial region is induced before physical interactions are established with the embryonic trophoblasts.…”

Section: Mechanisms Of Cell Death In the Uterusmentioning

confidence: 97%

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Apoptosis at the time of embryo implantation in mouse and rat

1999

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The aim of this review is to summarize the information currently available regarding the occurrence of apoptosis in the developing embryo and in the receptive uterus during the peri-implantation period of gestation. Cell death is detected in the inner cell mass of late pre-implantation embryos as the result of an eliminative process that helps trim the embryonic cell lineages of surplus or dysfunctional stem cells. Cell death is also detected in the epiblastic core of early postimplantation embryos, where the process is implicated in the formation of the pro-amniotic cavity. On the maternal side, uterine epithelial cells situated around the attachment site undergo cell death during the initial phase of implantation in order to facilitate embryo anchorage and access to maternal blood supply. Uterine stromal cells closest to the implantation chamber first transform into decidual cells and then commit suicide to make room for the rapidly growing embryo. Although apoptosis is well recognized as a crucial determinant of successful peri-implantation development, our understanding of the cellular and molecular mechanisms regulating this process clearly lags behind the comprehension of cell death control in other systems.

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Section: Mechanisms Of Cell Death In the Uterusmentioning

confidence: 72%

Section: Mechanisms Of Cell Death In the Uterusmentioning

confidence: 97%

Apoptosis at the time of embryo implantation in mouse and rat

1999

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“…Deciduoma, similar to the decidual response in normal pregnancy, can be induced by several artificial stimuli to uterine luminal surface in pseudopregnant rats and mice (Krehbiel, 1937; Velardo et al, 1953; Ohta, 1995; Andrade et al, 1996); however, life span of decidua or deciduoma is limited, being 12 days in unilaterally pregnant rats (Lyon and Allen, 1936) and 10 days in pseudopregnant mice (Atkinson, 1944). The presence of a limited life span in decidua or deciduoma suggested that the cell death is programmed in these tissues.…”

Section: Discussionmentioning

confidence: 99%

Apoptotic cell death in artificially induced deciduoma of pseudopregnant mice

et al. 1999

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Deciduoma induced by mechanical stimulation in pseudopregnant mice is similar to the decidua in normal pregnancy and it undergoes regression after a certain period. Therefore, we examined cell death in deciduomas which were induced by artificial stimulation. To analyze the regression mechanism of artificially induced deciduoma, DNA fragmentation, in situ 3'-DNA nick end labeling, and RT-PCR were performed on day 6 to 14 of pseudopregnancy. DNA fragmentation appeared on day 8 and it increased to day 10 of pseudopregnancy in the traumatized uterine horn. A large number of apoptotic cells were found on day 10 in the periphery of deciduoma at the antimesometrial side. Deciduoma underwent degeneration on day 11 of pseudopregnancy. Expression of tumor necrosis factor-alpha (TNF-alpha) mRNA was high on days 8 and 10, then decreased, whereas the expression increased again on day 14. TNF-alpha protein was expressed from day 8 to day 12, showing a peak expression on day 10 when deciduoma reached maximum weight. Serum progesterone level was high in the traumatized pseudopregnant mice on day 6, then it gradually decreased. Life span of deciduoma was prolonged 4 days more by daily injection of progesterone. A reduction in serum progesterone coincides with TNF-alpha increase, resulting in an increase of apoptotic deciduomal cells at the regression period, and that the life span of deciduoma is prolonged by additive supply of progesterone.

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“…A review of recent literature highlights the fact that the physical stimulus, not the signaling molecules of the implanting conceptus, elicits these changes, as long as the endometrium is properly hormonally “sensitized” for the deciduogenic stimulus (Kennedy and others, '07). Similar changes in vascular permeability and epithelial cell displacement can also occur in response to an artificial implantation stimulus in a non-pregnant endometrium that has been adequately sensitized for a deciduogenic stimulus (Lundkvist, '78; Milligan, '87; Milligan and Mirembe, '85; Andrade and others, '96). …”

Section: Introductionmentioning

confidence: 81%

Do molecular signals from the conceptus influence endometrium decidualization in rodents?

Herington

Bany

2009

J Exp Zool Pt B

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A critical period in establishing pregnancy occurs after the onset of implantation but before placental development. Evidence strongly suggests that abnormalities occurring during this period can result in pregnancy termination or in pre-eclampsia; the latter may lead to small-for-gestational-weight offspring that are likely to be unhealthy. Clearly, events occurring in the endometrium during the implantation process are crucial for proper fetal development and for optimal offspring health. In several mammalian species bi-directional communication between the conceptus and endometrium during implantation is required for successful pregnancy. Although different implantation and placentation modes occur in different mammalian species, common aspects of this bi-directional signaling may exist. The molecular signals from the trophoblast cells of the conceptus, which direct endometrial changes during implantation progression, are well known in some non-rodent species. Currently, we know little about such signaling in rodents during implantation progression, when the endometrium undergoes decidualization. This review focuses on data that support the hypothesis that paracrine signals from the rodent conceptus influence decidualization. Where possible, these findings are compared and contrasted to information currently known in other species that exhibit different implantation modes.

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Death and replacement of uterine epithelial cells during oil-induced deciduoma development in the mouse

Cited by 9 publications

References 28 publications

Apoptosis at the time of embryo implantation in mouse and rat

Apoptosis at the time of embryo implantation in mouse and rat

Apoptotic cell death in artificially induced deciduoma of pseudopregnant mice

Do molecular signals from the conceptus influence endometrium decidualization in rodents?

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