Death by bleomycin pulmonary toxicity in ovarian dysgerminoma with pathologic complete response to chemotherapy. A case report

Rodríguez, Julia Calzas; Morales, María del Carmen Juarez; Casero, Miguel Ángel Racionero

doi:10.1016/j.rmcr.2016.04.004

Cited by 5 publications

(10 citation statements)

References 15 publications

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“…Therefore, future management strategies may consider reducing direct pulmonary oxygen administration via ventilation to reduce oxidative stress in combination with antifibrotic therapies. Furthermore, preventative strategies such as patient age selection, cumulative dose reduction particularly in renally impaired patients, avoidance of concurrent mediastinal radiation therapy, as well as close monitoring of pulmonary function should be considered …”

Section: Discussionmentioning

confidence: 99%

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Bleomycin‐induced pulmonary toxicity and treatment with infliximab: A case report

Banakh

Tiruvoipati

et al. 2018

Clinical Case Reports

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Section: Discussionmentioning

confidence: 99%

“…Furthermore, preventative strategies such as patient age selection, cumulative dose reduction particularly in renally impaired patients, avoidance of concurrent mediastinal radiation therapy, as well as close monitoring of pulmonary function should be considered. [1][2][3][22][23][24]…”

Section: Discussionmentioning

confidence: 99%

Bleomycin‐induced pulmonary toxicity and treatment with infliximab: A case report

Banakh

Tiruvoipati

et al. 2018

Clinical Case Reports

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“…ethanol was sprayed from a positive capillary, and 96% ethanol was sprayed from a negative one. According to previous studies [ 32 ], the resulting aerosol is partially charged, so the chamber was covered with a grounded metal foil and closed with a metal mesh on top ( Figure 5 ).…”

Section: Methodsmentioning

confidence: 99%

“…BLM is clinically used as an antitumor antibiotic in the treatment of various cancers, including Hodgkin’s and non-Hodgkin’s lymphomas, ovarian cancer, melanoma, sarcoma, and squamous cell cancers [ 31 ]. BLM has also long been used in lung cancer chemotherapy [ 32 ]. However, it was reported that intravenous administration of BLM is associated with pulmonary fibrosis, and this effect can be reproduced in experimental animals [ 33 , 34 , 35 , 36 ].…”

Section: Introductionmentioning

confidence: 99%

Antitumor Effect of Bleomycin Nanoaerosol in Murine Carcinoma Model

et al. 2023

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Bleomycin, which is widely used as an antitumor agent, possesses serious adverse effects such as pulmonary toxicity. Local nanoaerosol deposition for lung cancer treatment is a promising alternative to drug delivery to lung lesions. The aim of this work is to test the hypothesis that bleomycin nanoaerosol can be effectively used to treat multiple lung metastases. To obtain bleomycin nanoaerosol, an aerosol generator based on electrospray of a solution of a nonvolatile substance with gas-phase neutralization of charged aerosol particles was used. Lung metastases in murine Lewis lung carcinoma and B16 melanoma animal models were counted. The effect of inhaled bleomycin nanoparticles on the number and volume of metastases, as well as pulmonary side effects, was investigated. Using a mouse exposure chamber, the dose-dependent effect of inhaled bleomycin on tumor volume was evaluated in comparison with intraperitoneal administration. Bleomycin nanoaerosol reduced the volume of metastases and produced a higher antitumor effect at much lower doses. It has been established that long-term exposure to nanoaerosol with a low dose of bleomycin is capable of suppressing cancer cell growth. The treatment was well tolerated. In the lungs, minor changes were found in the form of focal-diffuse infiltration of the lung parenchyma.

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“…[ 1 – 3 ] OD commonly occurs in young women, 90% of whom are younger than 30 years old (average age of 16–20 years old), and about 20% to 30% of patients are diagnosed during pregnancy. [ 4 – 6 ] OD has a rapid growth, and could result in complications such as rupture, hemoperitoneum or torsion, and an acute abdomen. [ 7 ] Here, we report a patient with OD who was diagnosed by 18 F-fluoro-2-deoxy-D-glucose-positron emission tomography/computed tomography ( 18 F-FDG PET/CT) in China.…”

Section: Introductionmentioning

confidence: 99%

Ovarian dysgerminoma detected by 18F-FDG PET/CT technique

Wang¹,

Feng²,

Dai³

et al. 2020

Medicine

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Introduction: Ovarian dysgerminoma (OD) mostly affect young women, have a rapid growth rate, and could result in complications such as rupture, hemoperitoneum or torsion, and acute abdomen. However, there have been no reports of OD on 18 F-FDG PET/CT imaging. Patient concerns: A 21-year-old female patient was admitted to our hospital on February 6, 2016, due to “reduced menstrual flow with abdominal distension for 3 months”. Diagnosis: Color Doppler ultrasound showed a large solid mass in the abdomen and pelvis. Serum carbohydrate antigen 125 (CA125) was elevated significantly. Subsequent computed tomography (CT) of chest showed a large effusion in the right thoracic cavity. Abdominal CT scan revealed the presence of a solid mass occupying a large space in the middle and lower abdomen, suggesting that it derived from the left ovary. Then, she underwent 18 F-fluoro-2-deoxy-D-glucose ( 18 F-FDG) positron emission tomography (PET)/CT examination for further diagnosis and staging. PET/CT showed a large occupying lesion in the abdomen. The maximum standardized uptake (SUV max ) of 18 F-FDG was 15.8. No obvious hypermetabolic metastases were observed in the other parts of the body. Postoperative pathology and immunohistochemistry confirmed the ovarian dysgerminoma. Interventions: The patient underwent surgery. Chemotherapy was successfully carried out post-operation. Outcomes: Fortunately, the patient is responding well to treatment and the postoperative recurrence-free survival time has been more than 3 years. Conclusion: OD usually occurs in young women and is characterized by large solid pelvic mass. The 18 F-FDG PET/CT scan shows abnormally increased metabolism of the tumor. Because of the high metabolic characteristics, 18 F-FDG PET/CT may be of great significance in the diagnosis and staging of OD.

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Death by bleomycin pulmonary toxicity in ovarian dysgerminoma with pathologic complete response to chemotherapy. A case report

Cited by 5 publications

References 15 publications

Bleomycin‐induced pulmonary toxicity and treatment with infliximab: A case report

Bleomycin‐induced pulmonary toxicity and treatment with infliximab: A case report

Antitumor Effect of Bleomycin Nanoaerosol in Murine Carcinoma Model

Ovarian dysgerminoma detected by 18F-FDG PET/CT technique

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