The article substantiates the conceptual foundations of the postmaterialistic paradigm of science, based on the achievements of quantum physics, synergetics, eniology and the theory of physical vacuum. The principles of the postmaterialistic paradigm (the ontological principle of holism, the principle of teleological hierarchy, the principle of materialistic-ideal complementarity, the anthropic principle of the predefinition of man and the world, the principle of the spiritual determiner of all theories of being) allowing to change radically the methods of energy use, applying the energy potential of the egregore for subtle, non-material matters of reality to upgrade the energy efficiency taking into account the axiological dominant, are explicated.