Death, end-stage renal disease and renal function decline in patients with diabetic nephropathy in French cohorts of type 1 and type 2 diabetes

Hadjadj, Samy; Cariou, Bertrand; Fumeron, Frédéric; Gand, Elise; Charpentier, G.; Roussel, Ronan; Kasmi, Ahmed-Amine; Gautier, Jean‐François; Mohammedi, K.; Gourdy, Pierre; Saulnier, Pierre‐Jean; Feigerlová, Eva; Marre, Michel; groups, Diabhycar study

doi:10.1007/s00125-015-3785-3

Cited by 49 publications

(45 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Microalbuminuria is not only a risk factor for end stage renal failure in diabetes but also an important marker of mortality in diabetic populations 1. ADA has stressed for early detection of microalbuminuria in diabetes patients as early treatment of microalbuminuria retard the progression of diabetic nephropathy 6.…”

Section: Discussionmentioning

confidence: 99%

“…As the burden of diabetes is increasing worldwide, more and more patients with diabetic nephropathy are surfacing. It has also been associated with increased morbidity and mortality and it is one of the most common cause of end stage renal disease(ESRD) and initiation of renal replacement therapy 1,2…”

Section: Introductionmentioning

confidence: 99%

“…From the early 80s, it was established that microalbuminuria is a good marker of subsequent proteinuria and chronic renal failure in both insulin and non-insulin dependent DM patients,6 but in Type-2 DM patient it has increased mortality rate mainly from cardiovascular diseases 1. It was also observed that these patients had concomitant hypertension as well when their microalbuminuria is diagnosed 7.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Microalbuminuria in Type-2 Diabetes Mellitus; the tip of iceberg of diabetic complications

Ahmad¹,

Ulhaq²,

Mawani³

et al. 2017

Pak J Med Sci

View full text Add to dashboard Cite

Objective:To determine the prevalence of microalbuminuria and its association with hypertension and other diabetic complications among Type-2 diabetic patients attending at Aga Khan University Hospital Karachi.Methods:1280 Type-2 diabetes patients who visited the outpatient department of Aga Khan University Hospital from September 2014 to August 2016 were included in the study. Microalbuminuria was diagnosed if spot urinary microalbumin excretion was confirmed to be more than 20mg/l. Hypertension was diagnosed if BP >140/90 or already on antihypertensive medications. Other demographic, clinical and laboratory data were also recorded.Results:Microalbuminuria was diagnosed in 404(31.56%) patients and among these albuminuric patients 335(82.9%) had hypertension. They were also dyslipidemic, having raised triglyceride levels, lower HDL levels, with more prevalence of background diabetic retinopathy and peripheral neuropathy. They also showed higher HbA1C levels and longer duration of diabetes.Conclusion:The prevalence of the microalbuminuria in our patients with Type-2 diabetes is 31.56% and is not only an early sign of diabetic nephropathy but also a host of other diabetic complications and should be dealt early with strict control of their hyperglycemia and hypertension to help prevent the future complications.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Microalbuminuria in Type-2 Diabetes Mellitus; the tip of iceberg of diabetic complications

Ahmad¹,

Ulhaq²,

Mawani³

et al. 2017

Pak J Med Sci

View full text Add to dashboard Cite

show abstract

“…Peritoneal dialysis does not need to establish vascular access, has little impact on hemodynamics, so elderly patients with diabetes tend to choose PD. Arteriosclerosis and the incidence of cardiovascular ,cerebrovascular events is often occurred in diabetic nephropathy [15,16]. Age is also a risk factor of vascular calci cation [17].…”

Section: Discussionmentioning

confidence: 99%

Characteristics and prognostic outcome factors in elderly peritoneal dialysis patients:a prospective observational study

Sun³

2020

Preprint

View full text Add to dashboard Cite

Background: This study aimed to analyze the characteristics, outcomes and prognosis factors of survival in elderly peritoneal dialysis patients, so as to better understand the status of elderly peritoneal dialysis patients and improve their quality of life.Methods: This study was a prospective, observational study that included peritoneal dialysis (PD)patients.Categorizing by age, elderly group aged ≥ 65, younger group aged < 65. Clinical characteristics, survival and transferring to hemodialysis were compared between two groups.Meanwhile, risk factors for death in elderly PD patients were explored.Results: A total of 202 PD patients were enrolled, including 61 in elderly group and 141 in younger group. Among elderly individuals,serum albumin and normalized protein catabolic rate(nPCR) decreased, the incidence of previous cardiovascular, cerebrovascular diseases and Charlson Comorbidity Index(CCI) were higher.The major primary disease in elderly patients was diabetic nephropathy, significant differences were found between elderly and younger group(P < 0.01). The mortality in elderly group was substantially higher, 27 patients (44.3%) died in elderly group and 21 patients(14.3%) died in younger group .The 1-year,2-year,3-year,4-year survival rate were 81.97%, 70.49%, 60.66%, 55.74% respectively. Cardiovascular disease was the main cause of death in elderly PD patients. Higher BMI, CCI, and previous ischemic heart disease were risk factors for long-term survival of elderly PD patients. Compared with the younger group, elderly patients were less likely to transfer to hemodialysis: 2 cases (3.3%) in elderly group and 23 cases (16.3%) in younger group. Peritonitis was the primary reason for converting to hemodialysis(HD) in both two groups.Conclusions: Poor nutrition, more complications and diabetic nephropathy were characteristics of elderly PD patients. High BMI, CCI and previous ischemic heart disease were independent predictors of death in elderly PD patients. Cardiovascular disease was the main cause of death in elderly PD patients，while the chief reason of transferring to hemodialysis was peritonitis.

show abstract

“…15.933 Caucasian patients with type 2 diabetes (defined by the American Diabetes Association criteria), attending consecutively 19 hospital-based Diabetes Clinics of the National Health Service throughout Italy in years 2007–2008 were recruited [16]. Next to the French SURDIAGENE study [17]. the German DIACORE project is another ongoing project with similarities to PROVALID [18].…”

Section: Discussionmentioning

confidence: 99%

A Prospective Cohort Study in Patients with Type 2 Diabetes Mellitus for Validation of Biomarkers (PROVALID) – Study Design and Baseline Characteristics

Eder

Leierer

Kerschbaum

et al. 2018

Kidney Blood Press Res

View full text Add to dashboard Cite

Background/Aims: The prevalence of diabetes mellitus type 2 and kidney disease in these patients varies widely between European countries. Methods: In addition to store bio-samples the “Prospective cohort study in patients with type 2 diabetes mellitus for validation of biomarkers” collects information on history, physical status, laboratory measurements and medication in 4000 patients with diabetes mellitus type 2, being taken care of at the primary level of healthcare in 5 European countries (Austria, Hungary, Netherlands, Poland and Scotland). Next to comparing the rate of loss of eGFR between the countries, a further objective of the PROVALID study is to determine the 5-year cumulative incidence of renal and cardiovascular outcomes. Results: The mean age of the population recruited is 62.9±10 years, 54.6% are male and the mean BMI is 30.9±5.4 kg/m². Metabolic control (median HBA1c 6.8 % (6.2; 7.5)) is achieved via administration of metformin in 67.4% of the patients and insulin in 30.3%. Median systolic and diastolic blood pressure at recruitment is 135 (125; 146) and 80 (72; 85) mmHg, 65.4% of subjects received RAAS blocking agents. Mean eGFR is 80.7±29.2 ml/min/1.73m² and median baseline albumin/creatinine ratio 8.3 mg (IQR: 3.8 and 25.1). Conclusion: PROVALID will provide information on incidence and progression of renal and cardiovascular disease and therapy in patients with type 2 diabetes mellitus in different European countries. Thus, in contrast to many other cohort studies we will be able to associate national clinical practise pattern with outcome in this highly vulnerable patient population.

show abstract

Death, end-stage renal disease and renal function decline in patients with diabetic nephropathy in French cohorts of type 1 and type 2 diabetes

Cited by 49 publications

References 27 publications

Microalbuminuria in Type-2 Diabetes Mellitus; the tip of iceberg of diabetic complications

Microalbuminuria in Type-2 Diabetes Mellitus; the tip of iceberg of diabetic complications

Characteristics and prognostic outcome factors in elderly peritoneal dialysis patients:a prospective observational study

A Prospective Cohort Study in Patients with Type 2 Diabetes Mellitus for Validation of Biomarkers (PROVALID) – Study Design and Baseline Characteristics

Contact Info

Product

Resources

About