Death From Asthma in Children

Richards, Warren; James, Patrick

doi:10.1001/archpedi.1965.02090030010003

Cited by 43 publications

(10 citation statements)

References 26 publications

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“…Among the 5-to 14-year age group, in 1972 asthma accounted for nearly twice as many bed-days as bronchitis and pneumonia combined, a reversal of the situation in 1960 (Table 1). Similar trends have been reported from Scotland (Lockwood, 1971) and from three different parts of the United States (Richards and Patrick, 1965;Falliers, 1970;Palm et al, 1970).…”

supporting

confidence: 83%

Increase in hospitalisation for childhood asthma.

Anderson¹

1978

Archives of Disease in Childhood

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SUMMARY Asthma admissions among children under 15 years of age have increased nearly threefold over the period 1959-73. The possible reasons for this increase have been examined using available data supplemented by the results of a special study of hospital disease indexes and case notes. Changes in diagnostic coding and trends in diagnostic fashion do not appear to be important. Part of the increase may be due to an increase in readmission rates. Changes in admission criteria resulting from changes in therapy, organisation of care, and illness behaviour have been considered. However, on present evidence an increase in morbidity cannot be excluded, and this could be investigated by repeat prevalence surveys of schoolchildren. If morbidity remains unchanged, admission policies for children with asthma should be reviewed.

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supporting

confidence: 83%

Increase in hospitalisation for childhood asthma.

Anderson¹

1978

Archives of Disease in Childhood

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“…These findings are now regarded as typical of asthma deaths, and the presence of acute inflammation is considered unusual (Dunnill, 1971). However, in the United States a number of reports have underlined the frequent presence of inflammation in the tracheobronchial tree, including bronchopneumonia, in children dying from asthma (Buranakul et al, 1974;Richards and Patrick, 1965). It is not clear why there should be such a contrast between British and US necropsy findings.…”

Section: Discussionmentioning

confidence: 99%

“…Severe attacks of asthma are particularly likely to occur following 'weaning' from these drugs (Maunsell et al, 1968 (Shenfield et al, 1975 (Dunnill, 1971). However, in the United States a number of reports have underlined the frequent presence of inflammation in the tracheobronchial tree, including bronchopneumonia, in children dying from asthma (Buranakul et al, 1974;Richards and Patrick, 1965 and 2) had the typical necropsy findings described by Fraser et al (1971) and did not have acute inflammatory changes in the lungs.…”

Section: Methodsmentioning

confidence: 99%

Asthma deaths in children--a continuing problem.

Mellis¹,

Phelan²

1977

Thorax

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“…The pathology of asthma was initially described in case series of fatal asthma [13,[248][249][250][251]. These largely qualitative descriptions highlighted common features, including: the infiltration of the airway wall with eosinophils, neutrophils and lymphomononuclear cells; occlusion of airway lumens with mucus, cellular debris and eosinophil products (Charcot-Leiden crystals); and thickening of the airway wall with prominence of the smooth muscle and mucous glands both in the epithelium and in the submucosa.…”

Section: Fatal Asthmamentioning

confidence: 99%

Clinical relevance of airway remodelling in airway diseases

James¹,

Wenzel²

2007

Eur Respir J

307

214

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Asthma and chronic obstructive pulmonary disease (COPD) are characterised by airflow obstruction, airway remodelling (measurable structural change) and inflammation. The present review will examine the relationship between airway remodelling in these two conditions with respect to symptoms, abnormal lung function, airway hyperresponsiveness and decline in lung function. The potential for remodelling to be a protective response will also be discussed.Asthma is associated with variable symptoms and changes in lung function and also fixed abnormalities of lung function and an increased rate of decline in lung function with age. There is a relative preservation of the relaxed airway lumen dimensions, prominent thickening of the smooth muscle layer and reduced airway distensibility. The severity of asthma is related to the degree of airway remodelling, which is most marked in cases of fatal asthma.In COPD, symptoms are persistent and predictable but also progressive and are related to fixed abnormalities of lung function. Remodelling is associated with narrowing of the airway lumen and an increased thickness of the airway wall, although not usually to the extent seen in asthma. COPD is most often due to smoking where there is also remodelling of the parenchyma that may contribute to symptoms.

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Death From Asthma in Children

Cited by 43 publications

References 26 publications

Increase in hospitalisation for childhood asthma.

Increase in hospitalisation for childhood asthma.

Asthma deaths in children--a continuing problem.

Clinical relevance of airway remodelling in airway diseases

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