Debromination Reaction of 2-Bromocarboxylic Acids

Synthesis of β-, γ-, δ-, ..., ω-Halogenated Ketones and Aldehydes

“…In one example, Polivin and co-workers reported on the thermal isomerization of 2-methyl-3-bromotetrahydropyran 1026 to terminally brominated methylketone 893 (Scheme 266). 262…”

“…Polivin and co-workers reported on the thermal isomerization of 2-methyl-3-bromotetrahydrofuran 682 to terminally brominated methylketone 664 (Scheme ) . Besides, De Buyck and co-workers described a one-pot route from tetrahydrofuran to 2,2,4-trichlorobutanal involving the isomerization of 2,3,3-trichlorotetrahydrofuran by AlCl 3 . , …”

“…Thermally induced ring-opening of halogenated cyclic ethers also provides an entry toward halo ketones. In one example, Polivin and co-workers reported on the thermal isomerization of 2-methyl-3-bromotetrahydropyran 1026 to terminally brominated methylketone 893 (Scheme ) …”