Decarboxylative dipropargylation of primary amines with propiolic acids and formaldehyde via metal-free coupling

Metal‐Free Decarboxylation of α,β‐Unsaturated Carboxylic Acids for Carbon–Carbon and Carbon–Heteroatom Coupling Reactions

“…In this work, less active bulky anilines such as 2,4,6‐trimethylaniline can be used for the construction of the corresponding products by cascade double decarboxylative A 3 ‐reaction (Scheme 3). [15] …”

Copper‐Catalyzed Double Decarboxylative Coupling Reactions of Alkynyl Carboxylic Acid and Glyoxylic Acid: Synthesis of Propargyl Amines and Imidazopyridines

“…Among them, the three‐component coupling reaction of an alkyne, aldehyde, and amine is a straightforward approach and one of the most widely used methods for their preparation (Scheme c). This multicomponent reaction has been achieved by using transition‐metal catalysts such as copper, palladium, gold, silver, and iridium as well as under metal‐free conditions . Glyoxylic acid derivatives have also been employed instead of the aldehyde in A 3 coupling and decarboxylative coupling reactions (Scheme d) .…”