Decavanadate and metformin-decavanadate effects in human melanoma cells

Sousa‐Coelho, Ana Luísa De; Aureliano, Manuel; Fraqueza, Gil; Serrão, Gisela; Gonçalves, João; Sánchez-Lombardo, Irma; Link, Wolfgang; Ferreira, Bibiana I.

doi:10.1016/j.jinorgbio.2022.111915

Cited by 21 publications

(24 citation statements)

References 89 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…For instance, it has been reported that POMs can inhibit α-glucosidase, an enzyme involved in the breakdown of complex carbohydrates, resulting in reduced blood glucose levels . Additionally, POMs have been shown to activate the insulin signaling pathway and stimulate glucose uptake in cells. , …”

Section: Introductionmentioning

confidence: 99%

Combined Experimental and Computational Study of V-Substituted Lindqvist Polyoxotungstate: Screening by Docking for Potential Antidiabetic Activity

Maalaoui,

Agwamba,

Louis

et al. 2023

Inorg. Chem.

View full text Add to dashboard Cite

In the current work, a novel vanadotungstate compound, (C 6 H 9 N 2 ) 4 [V 2 W 4 O 19 ]•2H 2 O (1), is isolated by a simple stepwise synthesis method and characterized by a combined experimental and computational study. Molecular docking is conducted for the first time for this kind of substituted Lindqvist polyoxometalates to elucidate for potential antidiabetic activity. Hence, the modeling results revealed a significant docking score of the reported compound to bind to the active sites of α-glucosidase with the lowest binding energy of −5.7 kcal/mol, where the standard drug acarbose (ACB) had −4.6 kcal/mol binding energy. The stability of binding was enhanced by strong H-bonding, van der Waals, and electrostatic interactions occurring in the threedimensional (3D) supramolecular network of polyanionic vanadotungstate subunits templated with organic moieties as shown by X-ray diffraction and Hirshfeld analyses. Furthermore, density functional theory (DFT) calculations supported with photophysical measurements are also discussed to predict the most chemical and biological reactivity. In this view, the complete description of electronic and biological features of (1) is enhanced by determination of the highest occupied molecular orbital (HOMO)/least unoccupied molecular orbital (LUMO) energy, electronic density, ionization potential, electron affinity, etc. These chemical descriptors, intermolecular interactions, docking score, and binding free energy estimation are essential in understanding the reactivity of this bioactive compound offering potential inhibition of the α-glucosidase enzyme.

show abstract

Section: Introductionmentioning

confidence: 99%

Combined Experimental and Computational Study of V-Substituted Lindqvist Polyoxotungstate: Screening by Docking for Potential Antidiabetic Activity

Maalaoui,

Agwamba,

Louis

et al. 2023

Inorg. Chem.

View full text Add to dashboard Cite

show abstract

“…At low concentrations, a large number of different complexes/compounds of vanadium were found to be therapeutically active [ 64 , 166 ]. Possible mechanisms for the anticancer activity of vanadium complexes/compounds included an increase in ROS generation, hyperactivation of the Ras-Raf-MEK-ERK pathway and cell cycle arrest [ 174 , 175 , 176 ]. It is also possible that vanadium may confer protection against chemical-induced carcinogenesis or toxicity in normal tissues by normalization of increased pathogenic LPO and oxidative stress.…”

Section: Vanadium Effects On Lipid Peroxidation and Disease Processesmentioning

confidence: 99%

Biological Consequences of Vanadium Effects on Formation of Reactive Oxygen Species and Lipid Peroxidation

Aureliano

Sousa‐Coelho

Dolan

et al. 2023

IJMS

Self Cite

View full text Add to dashboard Cite

Lipid peroxidation (LPO), a process that affects human health, can be induced by exposure to vanadium salts and compounds. LPO is often exacerbated by oxidation stress, with some forms of vanadium providing protective effects. The LPO reaction involves the oxidation of the alkene bonds, primarily in polyunsaturated fatty acids, in a chain reaction to form radical and reactive oxygen species (ROS). LPO reactions typically affect cellular membranes through direct effects on membrane structure and function as well as impacting other cellular functions due to increases in ROS. Although LPO effects on mitochondrial function have been studied in detail, other cellular components and organelles are affected. Because vanadium salts and complexes can induce ROS formation both directly and indirectly, the study of LPO arising from increased ROS should include investigations of both processes. This is made more challenging by the range of vanadium species that exist under physiological conditions and the diverse effects of these species. Thus, complex vanadium chemistry requires speciation studies of vanadium to evaluate the direct and indirect effects of the various species that are present during vanadium exposure. Undoubtedly, speciation is important in assessing how vanadium exerts effects in biological systems and is likely the underlying cause for some of the beneficial effects reported in cancerous, diabetic, neurodegenerative conditions and other diseased tissues impacted by LPO processes. Speciation of vanadium, together with investigations of ROS and LPO, should be considered in future biological studies evaluating vanadium effects on the formation of ROS and on LPO in cells, tissues, and organisms as discussed in this review.

show abstract

“…[6][7][8][9][10] Hence, polyoxovanadates (POVs) have received extensive interest due to their excellent biochemical property, catalytic behavior, and magnetism compared with polyoxomolybdates and polyoxotungstates. [11][12][13][14][15][16][17][18][19] In particular, the high coordination of vanadium allows to create the various types of vanadium-oxygen clusters such as {VO 4 }, {VO 5 }, {VO 6 }, and {VO 7 }. [20,21] Interestingly, the {VO 5 } cluster possesses the square pyramidal geometry mode capable of forming a series of POV spheres at the bottom of all the pyramids combined with the guest anion in the center.…”

Section: Introductionmentioning

confidence: 99%

“…Besides, the hard acidic property of vanadium affords an efficient combination with the O‐donor linkers of carboxylates or phosphonates to gain metal‐organic materials (MOMs) [6–10] . Hence, polyoxovanadates (POVs) have received extensive interest due to their excellent biochemical property, catalytic behavior, and magnetism compared with polyoxomolybdates and polyoxotungstates [11–19] . In particular, the high coordination of vanadium allows to create the various types of vanadium‐oxygen clusters such as {VO 4 }, {VO 5 }, {VO 6 }, and {VO 7 } [20,21] .…”

Section: Introductionmentioning

confidence: 99%

Syntheses, Structural Characterization, Optical and Magnetic Properties of a New Polyoxovanadate‐Based Metal‐Organic Polyhedron

Nguyen

Tran

2023

ChemistrySelect

View full text Add to dashboard Cite

A new polyoxovanadate‐based metal‐organic polyhedron, termed V‐MOP‐19, constructed from pentanuclear {V5O9Cl} clusters and 1,4‐naphthalenedicarboxylic acid linkers, was successfully fabricated via the solvothermal method. Structural analysis revealed that V‐MOP‐19 adopts the cubic symmetry featured with an octahedral pore cage of 15.7 Å. Full characterization of V‐MOP‐19 was measured by Fourier transform infrared (FT‐IR), Raman spectroscopy, powder X‐ray diffraction (PXRD), scanning electron microscopy (SEM), energy‐dispersive X‐ray (EDX), transmission electron microscopy (TEM), thermogravimetric and differential scanning calorimetry analysis (TGA‐DSC), N2 sorption isotherm and elemental analysis (EA). The band gap energy of V‐MOP‐19, measured by UV‐Vis diffuse reflectance spectroscopy (UV‐Vis/DRS), is determined to be 2.38 eV. Moreover, the cyclic voltammetry investigation confirms a high correspondence of the band gap value (2.41 eV) with the mentioned UV‐Vis/DRS study. In particular, V‐MOP‐19 exhibits a unique magnetic property with remarkable coercivity and remanent magnetization value. These findings demonstrate that V‐MOP‐19 could be used as a potential candidate in further photocatalytic and magnetic investigations.

show abstract

Decavanadate and metformin-decavanadate effects in human melanoma cells

Cited by 21 publications

References 89 publications

Combined Experimental and Computational Study of V-Substituted Lindqvist Polyoxotungstate: Screening by Docking for Potential Antidiabetic Activity

Combined Experimental and Computational Study of V-Substituted Lindqvist Polyoxotungstate: Screening by Docking for Potential Antidiabetic Activity

Biological Consequences of Vanadium Effects on Formation of Reactive Oxygen Species and Lipid Peroxidation

Syntheses, Structural Characterization, Optical and Magnetic Properties of a New Polyoxovanadate‐Based Metal‐Organic Polyhedron

Contact Info

Product

Resources

About