Decavanadate in vitro and in vivo effects: facts and opinions

Characterization of decavanadate and decaniobate solutions by Raman spectroscopy

“…Decavanadate ([V 10 O 28 6− ], V 10 ) is a member of a larger family of Group V and VI polyoxoanions commonly known as polyoxometalates (POMs). POMs have been found to have anti-diabetic, -bacterial, -protozoal, -viral and -cancer activities, which have sparked interest in their use as bio-inorganic drugs.…”

“…[1][2][3][4] Decavanadate is a homoleptic isopolyoxovanadate that interacts with high affinity with several proteins such as myosin, actin, and Ca 2+ -ATPase, thus affecting a range of cellular processes, including calcium homeostasis, muscle contraction, cytoskeleton dynamics and mitochondrial oxygen consumption. [4][5][6][7][8][9][10][11] Furthermore, the antidiabetic, anti-virus, anti-bacterial and anti-tumor activities of V 10 and vanadate compounds are attracting increasing interest. [12][13][14][15][16][17][18] Decavanadate also exhibits insulin-mimetic behavior, and it was shown that, upon incubation with decavanadate, rat adipocytes accumulate much more glucose than with well-established mimetic agents such as BMOV.…”

“…17 On the other hand, in vivo exposure to decavanadate, in comparison with vanadate, affects differently subcellular metal distribution, antioxidant enzyme activities, lipid peroxidation and tissue damage in several organs. 4,9,10,19 Recently, decavanadate has also found application in other processes such as aerobic oxidation of starch, solar-driven photocatalysis and protein crystallography. [20][21][22] Depending on factors such as vanadate concentration, pH and ionic strength, different vanadate oligomeric species can occur simultaneously in vanadium(V) solutions, including monomeric (V 1 4,23,24 These ortho and metavanadate species are comprised of tetrahedral vanadate units.…”

“…[20][21][22] Depending on factors such as vanadate concentration, pH and ionic strength, different vanadate oligomeric species can occur simultaneously in vanadium(V) solutions, including monomeric (V 1 4,23,24 These ortho and metavanadate species are comprised of tetrahedral vanadate units. In addition to them, the decavanadate ion, V 10 , which consists of octahedral vanadate units, also occurs in solution. Its presence is easily detected due to the strong orange-yellow colour of V 10 compared with the colourless ortho and metavanadates.…”

“…The disappearance of the decamer follows a first-order kinetic process and can be easily followed by UV/Vis spectroscopy by recording the absorption band at 400 nm as a function of time. [4][5][6] In addition, V 10 sition may be prevented through binding to specific proteins, which apparently retard dissociation. Increases in the half-life from 5 to 17 hours in the presence of sarcoplasmic reticulum vesicles, and to 27 hours in the presence of actin were found at room temperature and pH 7.0, 25 whereas no effects were observed with myosin, even though it is known to have a highaffinity V 10 -binding site.…”