Decay of 78.4 h 89Zr

Hinrichsen, P.F.

doi:10.1016/0375-9474(68)90438-7

Cited by 18 publications

(4 citation statements)

References 12 publications

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“…After submission of this paper, it was pointed out to me by Hinrichsen [7] that ζ can be related to standard exponents. If we assume that the density in the time reversed cluster decays radially, from a value near unity, as r −zδ with a radial cutoff at r c ∼ t 1/z , then…”

Section: Resultsmentioning

confidence: 99%

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Local persistence in directed percolation

Grassberger¹

2009

J. Stat. Mech.

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We reconsider the problem of local persistence in directed site percolation. We present improved estimates of the persistence exponent in all dimensions from 1 + 1 to 7 + 1, obtained by new algorithms and by improved implementations of existing ones. We verify the strong corrections to scaling for 2 + 1 and 3 + 1 dimensions found in previous analyses, but we show that scaling is much better satisfied for very large and very small dimensions. (2008)). These results are mainly based on efficient simulations of clusters evolving under the time reversed dynamics with a permanently active site and a particular survival condition discussed in Fuchs et al.. These simulations suggest also a new critical exponent ζ which describes the growth of these clusters conditioned on survival, and which turns out to be the same as the exponent, η + δ in standard notation, of surviving clusters under the standard DP evolution.

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Section: Resultsmentioning

confidence: 99%

“…The growth of the mass of such clusters, conditioned on their survival, can be described using an exponent ζ. As pointed out by Hinrichsen after this paper was written [7], a heuristic argument relates ζ to a combination of standard DP exponents which can be rewritten, using hyperscaling and the standard notation for DP exponents [8], as…”

Section: Introductionmentioning

confidence: 99%

Local persistence in directed percolation

Grassberger¹

2009

J. Stat. Mech.

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“…Any discussion of PET imaging with 89 Zr must necessarily begin with the fundamentals its decay [24-28]. 89 Zr decays with a half-life of 78.41 h via both positron emission and electron capture to an intermediate 89m Y state which in turn decays to stable 89 Y via a gamma ray emission (909 keV) with a half-life of 15.7 s (Figure 1).…”

Section: Decay Characteristicsmentioning

confidence: 99%

PET imaging with 89Zr: From radiochemistry to the clinic

Deri

Zeglis

Francesconi

et al. 2013

Nuclear Medicine and Biology

358

389

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The advent of antibody-based cancer therapeutics has led to the concomitant rise in the development of companion diagnostics for these therapies, particularly nuclear imaging agents. A number of radioisotopes have been employed for antibody-based PET and SPECT imaging, notably 64Cu, 124I, 111In, and 99mTc; in recent years, however, the field has increasingly focused on 89Zr, a radiometal with near ideal physical and chemical properties for immunoPET imaging. In the review at hand, we seek to provide a comprehensive portrait of the current state of 89Zr radiochemical and imaging research, including work into the production and purification of the isotope, the synthesis of new chelators, the development of new bioconjugation strategies, the creation of novel 89Zr-based agents for preclinical imaging studies, and the translation of 89Zr-labeled radiopharmaceuticals to the clinic. Particular attention will also be dedicated to emerging trends in the field, 89Zr-based imaging applications using vectors other than antibodies, the comparative advantages and limitations of 89Zr-based imaging compared to that with other isotopes, and areas that would benefit from more extensive investigation. At bottom, it is hoped that this review will provide both the experienced investigator and new scientist with a full and critical overview of this exciting and fast-developing field.

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“…Zirconium-89 is a positron emitting radiometal with a 3.27 day half-life and a mean positron energy of 396 keV. It also emits 909 keV cascade gamma rays but with sufficient delay that they do not cause spurious coincidences [1] . These properties, along with its tendency to residualize in cells, make 89 Zr an increasingly popular choice as a radiolabel for PET imaging studies of in vivo antibody distribution.…”

Section: Introductionmentioning

confidence: 99%

A Recommendation for Revised Dose Calibrator Measurement Procedures for 89Zr and 124I

et al. 2014

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Because of their chemical properties and multiday half lives, iodine-124 and zirconium-89 are being used in a growing number of PET imaging studies. Some aspects of their quantitation, however, still need attention. For 89Zr the PET images should, in principle, be as quantitatively accurate as similarly reconstructed 18F measurements. We found, however, that images of a 20 cm well calibration phantom containing 89Zr underestimated the activity by approximately 10% relative to a dose calibrator measurement (Capintec CRC-15R) using a published calibration setting number of 465. PET images of 124I, in contrast, are complicated by the contribution of decays in cascade that add spurious coincident events to the PET data. When these cascade coincidences are properly accounted for, quantitatively accurate images should be possible. We found, however, that even with this correction we still encountered what appeared to be a large variability in the accuracy of the PET images when compared to dose calibrator measurements made using the calibration setting number, 570, recommended by Capintec. We derive new calibration setting numbers for 89Zr and 124I based on their 511 keV photon peaks as measured on an HPGe detector. The peaks were calibrated relative to an 18F standard, the activity level of which was precisely measured in a dose calibrator under well-defined measurement conditions. When measuring 89Zr on a Capintec CRC-15R we propose the use of calibration setting number 517. And for 124I, we recommend the use of a copper filter surrounding the sample and the use of calibration setting number 494. The new dose calibrator measurement procedures we propose will result in more consistent and accurate radioactivity measurements of 89Zr and 124I. These and other positron emitting radionuclides can be accurately calibrated relative to 18F based on measurements of their 511 keV peaks and knowledge of their relative positron abundances.

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Decay of 78.4 h 89Zr

Cited by 18 publications

References 12 publications

Local persistence in directed percolation

Local persistence in directed percolation

PET imaging with 89Zr: From radiochemistry to the clinic

A Recommendation for Revised Dose Calibrator Measurement Procedures for 89Zr and 124I

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