Deceased-donor lobar lung transplant: A successful strategy for small-sized recipients

Cruz, José Luis Campo-Cañaveral de la; Dunne, Ben; Lemaître, Philippe; Račkauskas, Mindaugas; Pozniak, J.; Watanabe, Y.; Mariscal, A.; Yeung, Jonathan C.; Yasufuku, Kazuhiro; Pierre, Andrew; Perrot, Marc de; Waddell, Thomas K.; Cypel, Marcelo; Keshavjee, S.; Donahoe, Laura

doi:10.1016/j.jtcvs.2020.04.166

Cited by 18 publications

(12 citation statements)

References 28 publications

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“…2 In this issue of the Journal, the Toronto group reported one of the largest published series of cadaveric LLTxbetween 2000 and 2017, they performed 75 LLTx procdures. 3 Pulmonary fibrosis was the most common diagnosis, and similar to previous reports, recipients of LLTx were more likely to be rapidly deteriorating and required bridging by mechanical ventilation or extracorporeal life support. [4][5][6][7] When compared with standard LTx, their recipients of LLTx were more likely to have postoperative primary graft dysfunction grade 3 or extracorporeal membrane oxygenation and longer intensive care unit and hospital length of stay.…”

supporting

confidence: 73%

Commentary: Small can be beautiful, in the right hands

Lee

Hsin

2021

The Journal of Thoracic and Cardiovascular Surgery

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supporting

confidence: 73%

Commentary: Small can be beautiful, in the right hands

Lee

Hsin

2021

The Journal of Thoracic and Cardiovascular Surgery

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“…Several strategies have been advocated to palliate the scarcity of available organs such as ex vivo lung perfusion (EVLP) [1], optimizing donor management in intensive care units (ICU) [2], living donations [3], lobar transplantation [4] and donation after circulatory death (DCD) [5–14].…”

Section: Introductionmentioning

confidence: 99%

Lung transplantation from uncontrolled and controlled donation after circulatory death: similar outcomes to brain death donors

Cruz

Carrasco

Tanaka

et al. 2021

Transplant International

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Summary Controlled donation after circulatory death donors (cDCD) are becoming a frequent source of lungs grafts worldwide. Conversely, lung transplantations (LTx) from uncontrolled donors (uDCD) are sporadically reported. We aimed to review our institutional experience using both uDCD and cDCD and compare to LTx from brain death donors (DBD). This is a retrospective analysis of all LTx performed between January 2013 and December 2019 in our institution. Donor and recipient characteristics were collected and univariate, multivariate and survival analyses were carried out comparing the three cohorts of donors. A total of 239 (84.7%) LTx were performed from DBD, 29 (10.3%) from cDCD and 14 (5%) from uDCD. There were no statistically significant differences in primary graft dysfunction grade 3 at 72 h, 30‐ and 90‐day mortality, need for extracorporeal membrane oxygenation after procedure, ICU and hospital length of stay, airway complications, CLAD incidence or survival at 1 and 3 years after transplant (DBD: 87.1% and 78.1%; cDCD: 89.7% and 89.7%; uDCD: 85.7% and 85.7% respectively; P = 0.42). Short‐ and mid‐term outcomes are comparable between the three types of donors. These findings may encourage and reinforce all types of donation after circulatory death programmes as a valid and growing source of suitable organs for transplantation.

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“…Pulmonary fibrosis patients may deteriorate rapidly, and they constitute the commonest group for cadaveric lobar transplantation. [ 1 ] Donor size-matching may be challenging because of the small chest cavities of these patients. Recipient 1 had bilateral pneumonia, and therefore single LTx was not suitable and she required bilateral lung transplantation.…”

mentioning

confidence: 99%

“…While graft downsizing by wedge resection is an option, when the donor/recipient pTLC mismatch exceeds 1 L, downsizing by lobectomy is recommended. [ 1 ] Couetil et al [ 3 ] first reported bipartitioning of a cadaveric donor left lung for bilateral lobar LTx. The use of inverted lobar LTx has been described in living lobar LTx, usually implanting a donor right lower lobe or middle lobe to the left side.…”

mentioning

confidence: 99%

Bilateral lobar lung transplantation and a single lung transplantation using lungs from a single organ donor during coronavirus disease 2019 pandemic

Liu

Hsin

et al. 2021

Chinese Medical Journal

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To the Editor: During the coronavirus disease 2019 (COVID-19) pandemic in China, cadaveric organ donation became drastically reduced, which exacerbated the waitlist morbidity and mortality of lung transplant (LTx) patients. We report a case where we were able to maximize the utilization of the lungs from a single cadaveric donor by performing a single left LTx for one recipient using the donor's left lung, and by bipartitioning the donor's right lung, we were able to perform bilateral lobar transplantation for another recipient.

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Deceased-donor lobar lung transplant: A successful strategy for small-sized recipients

Cited by 18 publications

References 28 publications

Commentary: Small can be beautiful, in the right hands

Commentary: Small can be beautiful, in the right hands

Lung transplantation from uncontrolled and controlled donation after circulatory death: similar outcomes to brain death donors

Bilateral lobar lung transplantation and a single lung transplantation using lungs from a single organ donor during coronavirus disease 2019 pandemic

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