Deceased donor renal transplantation at army hospital research and referral: Our experience

Swami, Yogesh Kumar; Singh, Dharam Raj; Pradhan, Aditya; Rana, Yajvender Pratap Singh; Harkar, Sandeep; Wani, M. Shafi

doi:10.4103/0970-1591.114029

Cited by 12 publications

(7 citation statements)

References 35 publications

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“…[12] In our study, 48.5% had DGF, 21.8% had acute rejection, mean CIT was 5.66 h, 1 and 5 years patient survival 80.2% and 76.3% and graft survival 82.6% and 80%, respectively. When compared to other Indian studies,[131415] the incidence of DGF was higher in our study despite having shorter mean cold ischemic time [Table 5]. …”

Section: Discussioncontrasting

confidence: 64%

Deceased donor renal transplantation: A single center experience

Gopalakrishnan¹,

Dineshkumar²,

Dhanapriya³

et al. 2017

Indian J Nephrol

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Deceased donor renal transplantation (DDRT) constitutes less than 5% of all kidney transplantats in India. A retrospective analysis of 173 deceased donor renal transplants performed in a public funded government hospital was done. Mean age of the recipients was 36 years (male:female ratio 2.4:1), and that of the donors was 32.3 years (male:female ratio 6:1). The cold ischemic time was 340 ± 170 minutes. Mean follow-up period was 36 months. Forty one patients died, 75% of them in the first post – transplant year. Sepsis and cardiovascular disease were the most common causes of death. Twenty two percent had acute rejection. There was no significant difference in the incidence in the rate of acute rejection, bacterial, fungal infections and death rate between the cohorts of induction and non induction immunosuppression. The patient and death censored graft survival at 1 year were 80 and 82.6% and at 5 years were 76 and 80% respectively.

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Section: Discussioncontrasting

confidence: 64%

Deceased donor renal transplantation: A single center experience

Gopalakrishnan¹,

Dineshkumar²,

Dhanapriya³

et al. 2017

Indian J Nephrol

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“…In India, approximately 175,000 patients are added each year to the pool of ESRD; however, only 10% of these receive RRT and 2.4% patients receive RT. 1 A limited number of live donor (LRD) availabilities are one of the major reasons for this huge demand and supply gap. A deceased donor (DD) RT program is the possible solution to the widening demand supply gap for kidney donors.…”

Section: Introductionmentioning

confidence: 99%

“…A deceased donor (DD) RT program is the possible solution to the widening demand supply gap for kidney donors. 1 The rate of RT performed yearly in India translates to 3.25 per million populations (PMP); the deceased-donation rate is 0.08 PMP per year. This discrepancy between the number of waiting patients and RT performed can be reduced by developing a DDRT program.…”

Section: Introductionmentioning

confidence: 99%

Outcome of renal transplantation from deceased donors: experience from developing country

et al. 2014

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Background: In India, there are a large number of end-stage renal disease (ESRD) patients waiting for renal transplantation (RT). Organ retrieval from brain dead deceased donor (DD) is getting increased attention as the waiting list for organ recipients far exceeds the organ donor pool. In our country, despite a large population, the number of brain dead donors undergoing organ donation is very less. DDRT is the possible solution to bridge the disparity between organ supply and demand. In India, the potential for DDRT is huge due to the high number of fatal road traffic accidents and this pool is yet to be tapped. Patients and methods: We report DDRT outcome in 294 patients (age: 36.5 ± 14.1 years; male:female, 200:94) between 2005 and 2012. All patients received single-dose rabbit-anti-thymocyte globulin for induction and steroids, calcineurin inhibitor, and mycophenolate mofetil/azathioprine for maintenance immunosuppression. Results: Our retrospective study in 294 DDRT shows a fairly successful outcome. Over a mean follow-up of 3.93 years, patient and graft survival rates were 81.7% and 92.6%, respectively, with a median serum creatinine of 1.5 mg/dL. 20.7% had biopsy-proven acute rejection. Conclusion: Given the widespread organ shortage, DDRT has a potential to expand the donor pool and shorten the waiting list for RT, encouraging the use of this approach even in low-income countries. Aggressive donor management, increasing public awareness about the concept of organ donation, good communication between clinician and the family members, and a well-trained team of transplant coordinators can help in improving the number of organ donations.

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“…Post-transplant, 15 patients (34%) had DGF [due to Acute Tubular Necrosis (ATN) in 7 patients, acute cellular rejection in 5, and antibody-mediated rejection in 2 patients. [ 14 ]…”

Section: Discussionmentioning

confidence: 99%

Deceased donor renal transplantation: A single center experience

et al. 2021

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Introduction: Deceased donor kidney transplant are still not common across India. This study was done to assess various measures taken at a single center level to increase organ donation rate and to analyse the outcomes of transplants performed from these donors. Methods: All deceased donor renal transplants performed from November 2011 to February 2017 were analysed for patient and death censored graft survival, rate of delayed graft function, rate of rejection and mortality. Kaplan Meir analysis for Survival Curves was used. Results: Organ donation rate at our center improved from one donation every alternate year in 2004 to a peak of 44 donations in 2017. Patient survival was 93.42%, 89.44%, 85.53%, and death censored graft survival was 94.07%, 88.21%, and 82.86% at 1, 2 and 3 years respectively. Mean duration of hemodialysis pre transplantation was 34.6 ± 27.43 months. Conclusions: This study has shown that steps taken at a single center level alone can also significantly improve organ donation rates. Employment of dedicated professionals including transplant surgeons and coordinators, developing a protocol-based approach for referral, and early counseling in triage along with regular audits can help to establish deceased donor program with acceptable outcomes elsewhere in the country.

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Deceased donor renal transplantation at army hospital research and referral: Our experience

Cited by 12 publications

References 35 publications

Deceased donor renal transplantation: A single center experience

Deceased donor renal transplantation: A single center experience

Outcome of renal transplantation from deceased donors: experience from developing country

Deceased donor renal transplantation: A single center experience

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