Decellularized extracellular matrix scaffold seeded with adipose-derived stem cells promotes neurorestoration and functional recovery after spinal cord injury through Wnt/β-catenin signaling pathway regulation

Su, Xiaochen; Teng, Menghao; Zhang, Yingang; Ji, Wenchen

doi:10.1088/1748-605x/ad0fa1

Cited by 3 publications

(2 citation statements)

References 42 publications

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“…ESCs [222], iPSCs [43,223], NSCs/NPCs [224,225], MSCs [180,181], OPCs [226], DPSCs [216] and ADSCs [227] Olfactory ensheathing cells [228] and Schwann cells [229] Microglia [230] Directly reprogrammed NPCs (drNPCs) [231][232][233] Gene therapies Nucleic acid-based therapies Delivery methods Other siRNA to AQP-4 [234], nNOS [235], iNOS [236], IL-6 [237], claudin-5 [238], RhoA [239,240], PLK-4 [241], PTEN [242,243], Sema3A [244], CTGF [245], combinatorial [246] and in combination with MSCs [242] Nanoparticle-coated siRNA [247][248][249], polymer nanocarriers [239], exosome delivery [243,245] extracellular vesicles [250], intrathecal delivery [240], photomechanical wave [251] and intranasal delivery [242] Chemogenetic stimulation [252]…”

Section: Neural Cells Immune Cells Advanced Cell Therapiesmentioning

confidence: 99%

“…Other Hydrogels [180,181,253,254], PLGA [255] and PLA [256] Collagen [181,257], CS [258], silk [259,260], decellularised ECM [227], modified gelatine [261] R-GSIK [262], electrospun nanofiber nets [263] and gene scaffolds [264] Gold nanoparticle nerve guidance conduits [265] and collagen conduits [266] Graphene oxide [267], IGF-1 delivery via nanofibrous dural substitutes [197] and ROS scavenger materials [170,171] Table 2. Cont.…”

Section: Nerve Guidancementioning

confidence: 99%

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Neurotrauma—From Injury to Repair: Clinical Perspectives, Cellular Mechanisms and Promoting Regeneration of the Injured Brain and Spinal Cord

Stevens,

Belli,

Ahmed

2024

Biomedicines

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Traumatic injury to the brain and spinal cord (neurotrauma) is a common event across populations and often causes profound and irreversible disability. Pathophysiological responses to trauma exacerbate the damage of an index injury, propagating the loss of function that the central nervous system (CNS) cannot repair after the initial event is resolved. The way in which function is lost after injury is the consequence of a complex array of mechanisms that continue in the chronic phase post-injury to prevent effective neural repair. This review summarises the events after traumatic brain injury (TBI) and spinal cord injury (SCI), comprising a description of current clinical management strategies, a summary of known cellular and molecular mechanisms of secondary damage and their role in the prevention of repair. A discussion of current and emerging approaches to promote neuroregeneration after CNS injury is presented. The barriers to promoting repair after neurotrauma are across pathways and cell types and occur on a molecular and system level. This presents a challenge to traditional molecular pharmacological approaches to targeting single molecular pathways. It is suggested that novel approaches targeting multiple mechanisms or using combinatorial therapies may yield the sought-after recovery for future patients.

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Section: Neural Cells Immune Cells Advanced Cell Therapiesmentioning

confidence: 99%

Section: Nerve Guidancementioning

confidence: 99%

Neurotrauma—From Injury to Repair: Clinical Perspectives, Cellular Mechanisms and Promoting Regeneration of the Injured Brain and Spinal Cord

Stevens,

Belli,

Ahmed

2024

Biomedicines

View full text Add to dashboard Cite

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Multiple sclerosis treatments a review of current biomedical engineering approaches

Mohseni,

Au,

Issa

et al. 2025

Biomaterials

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Wnt signaling pathway in spinal cord injury: from mechanisms to potential applications

Li,

Chen,

Chang

et al. 2024

Front. Mol. Neurosci.

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Spinal cord injury (SCI) denotes damage to both the structure and function of the spinal cord, primarily manifesting as sensory and motor deficits caused by disruptions in neural transmission pathways, potentially culminating in irreversible paralysis. Its pathophysiological processes are complex, with numerous molecules and signaling pathways intricately involved. Notably, the pronounced upregulation of the Wnt signaling pathway post-SCI holds promise for neural regeneration and repair. Activation of the Wnt pathway plays a crucial role in neuronal differentiation, axonal regeneration, local neuroinflammatory responses, and cell apoptosis, highlighting its potential as a therapeutic target for treating SCI. However, excessive activation of the Wnt pathway can also lead to negative effects, highlighting the need for further investigation into its applicability and significance in SCI. This paper provides an overview of the latest research advancements in the Wnt signaling pathway in SCI, summarizing the recent progress in treatment strategies associated with the Wnt pathway and analyzing their advantages and disadvantages. Additionally, we offer insights into the clinical application of the Wnt signaling pathway in SCI, along with prospective avenues for future research direction.

show abstract

Decellularized extracellular matrix scaffold seeded with adipose-derived stem cells promotes neurorestoration and functional recovery after spinal cord injury through Wnt/β-catenin signaling pathway regulation

Cited by 3 publications

References 42 publications

Neurotrauma—From Injury to Repair: Clinical Perspectives, Cellular Mechanisms and Promoting Regeneration of the Injured Brain and Spinal Cord

Neurotrauma—From Injury to Repair: Clinical Perspectives, Cellular Mechanisms and Promoting Regeneration of the Injured Brain and Spinal Cord

Multiple sclerosis treatments a review of current biomedical engineering approaches

Wnt signaling pathway in spinal cord injury: from mechanisms to potential applications

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