2022
DOI: 10.3390/jfb13040171
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Decellularized Pancreatic Tail as Matrix for Pancreatic Islet Transplantation into the Greater Omentum in Rats

Abstract: Infusing pancreatic islets into the portal vein currently represents the preferred approach for islet transplantation, despite considerable loss of islet mass almost immediately after implantation. Therefore, approaches that obviate direct intravascular placement are urgently needed. A promising candidate for extrahepatic placement is the omentum. We aimed to develop an extracellular matrix skeleton from the native pancreas that could provide a microenvironment for islet survival in an omental flap. To that en… Show more

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Cited by 8 publications
(1 citation statement)
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“…In pancreatic, diabetes mellitus causes a decrease in organ parts. The 3D structure is critical for subsequent cell survival and performance (13,14). Clinical trials have been conducted with bioengineered tissues and organs, such as synthetic bladders, tracheas, nasal cartilage, and tubular tissue (15,16).…”
Section: Discussionmentioning
confidence: 99%
“…In pancreatic, diabetes mellitus causes a decrease in organ parts. The 3D structure is critical for subsequent cell survival and performance (13,14). Clinical trials have been conducted with bioengineered tissues and organs, such as synthetic bladders, tracheas, nasal cartilage, and tubular tissue (15,16).…”
Section: Discussionmentioning
confidence: 99%