2022
DOI: 10.1111/aor.14399
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Decellularized tympanic membrane scaffold with bone marrow mesenchymal stem cells for repairing tympanic membrane perforation

Abstract: Background Tympanic membrane perforation (TMP) is a common disease in otology, and few acellular techniques have been reported for repairing this condition. Decellularized extracellular matrix (ECM) scaffolds have been used in organ reconstruction. Objective This study on tissue engineering aimed to develop a tympanic membrane (TM) scaffold prepared using detergent immersion and bone marrow mesenchymal stem cells (BMSCs) as repair materials to reconstruct the TM. Results General structure was observed that the… Show more

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Cited by 4 publications
(2 citation statements)
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“…11−14 In the literature, decellularized and polymer-based scaffolds have been promising in the field of tympanic membrane tissue engineering. 11,14 Poly(lactic-coglycolic acid) (PLGA), a polymer material approved by the FDA, 15 is commonly used because of its excellent biocompatibility and biodegradability. 16,17 However, conventional PLGA scaffolds lack antibacterial properties.…”
Section: Introductionmentioning
confidence: 99%
See 1 more Smart Citation
“…11−14 In the literature, decellularized and polymer-based scaffolds have been promising in the field of tympanic membrane tissue engineering. 11,14 Poly(lactic-coglycolic acid) (PLGA), a polymer material approved by the FDA, 15 is commonly used because of its excellent biocompatibility and biodegradability. 16,17 However, conventional PLGA scaffolds lack antibacterial properties.…”
Section: Introductionmentioning
confidence: 99%
“…Recent advances in tissue engineering have led to the development of various biomaterials and strategies that can be used for TMP repair. In the literature, decellularized and polymer-based scaffolds have been promising in the field of tympanic membrane tissue engineering. , Poly­(lactic- co -glycolic acid) (PLGA), a polymer material approved by the FDA, is commonly used because of its excellent biocompatibility and biodegradability. , However, conventional PLGA scaffolds lack antibacterial properties. Loading antibiotics can help address this issue; however, achieving controlled drug release remains challenging. , …”
Section: Introductionmentioning
confidence: 99%