“…Broadly, MDD is associated with a loss of biological and behavioral flexibility (Kashdan & Rottenberg, 2010; Stange, Alloy, & Fresco, in press). Specifically, MDD is characterized by inflexible physiological responses (Bylsma, Salomon, Taylor-Clift, Morris, & Rottenberg, 2014), difficulty disengaging from perseverative thinking processes such as rumination, and with mentally distancing oneself from one’s negative thinking (Nolen-Hoeksema, Wisco, & Lyubomirsky, 2008; Fresco et al, 2007a; Bernstein et al, 2015). Furthermore, healthy individuals who are inflexible in response to changes in environmental or emotional context also may be susceptible to developing depression (Stange et al, in press).…”