Background: There is a relative dearth of research on patients with Parkinson′s disease (PD) from underrepresented ethnic groups in the United Kingdom.Objectives: The East London Parkinson′s Disease project seeks to understand the clinical manifestations and determinants of PD in a diverse population.Methods: Patients with PD were recruited from the Royal London Hospital. Healthy controls came from community engagement events and partners of patients. Data on clinical features assessed by motor and non-motor scales were collected between January 2019 and February 2024, and compared between groups. Parametric, non-parametric tests, and unmatched logistic models, adjusted for age, gender and duration of disease were used.Results: We assessed 218 patients with PD and 90 controls. Among them, 50% of patients and 64% controls identified as South Asian or Black. Males comprised 63% of patients and 70% of controls. After adjusting for age, gender, disease duration and treatment burden, South Asian and Black patients had significantly worse motor scores compared to White patients (mean [SD], 42.2 [18.8], and 47 [16.6] vs 35.2 [16.4], p<0.001 and p<0.001). Cognitive impairment was more prevalent in South Asian (73%) and Black patients (75%) than in White patients (45%, p=0.002).Conclusions: Our results suggest that patients with PD from South Asian and Black ethnic groups may have more severe motor and certain non-motor features, including cognitive impairment, compared to White patients.