Deception in the Pursuit of Science

Wendler, David; Miller, Franklin G.

doi:10.1001/archinte.164.6.597

Cited by 94 publications

(72 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Subsequently, in accordance with guidelines for ethically appropriate authorized deception (Wendler & Miller, 2004), participants were debriefed about the deception involved in the task and the motivation for its use. They and their parents had been informed at consent that during the study protocol they would be given misleading or inaccurate information about a task, but they were not told when this would occur.…”

Section: Methodsmentioning

confidence: 99%

Responses to Conflict and Cooperation in Adolescents with Anxiety and Mood Disorders

McClure

Parrish

Nelson

et al. 2007

J Abnorm Child Psychol

View full text Add to dashboard Cite

This study examined patterns of behavioral and emotional responses to conflict and cooperation in adolescents with anxiety/mood disorders and healthy peers. We compared performance on and emotional responses to the Prisoner's Dilemma (PD) game, an economic exchange task involving conflict and cooperation, between adolescents with anxiety/depressive disorders (A/D) (N=21) and healthy comparisons (n=29). Participants were deceived to believe their co-player (a pre-programmed computer algorithm) was another study participant. A/D adolescents differed significantly from comparisons in patterns of play and emotional response to the game.Specifically, A/D participants responded more cooperatively to cooperative overtures from their co-players; A/D girls also reported more anger toward co-players than did comparison girls. Our findings indicate that A/D adolescents, particularly females, respond distinctively to stressful social interchanges. These findings offer a first step toward elucidating the mechanisms underlying social impairment in youth with internalizing disorders.

show abstract

Section: Methodsmentioning

confidence: 99%

Responses to Conflict and Cooperation in Adolescents with Anxiety and Mood Disorders

McClure

Parrish

Nelson

et al. 2007

J Abnorm Child Psychol

View full text Add to dashboard Cite

show abstract

“…Providing participants the opportunity to withdraw their data also may limit the generalizability of research findings [26] and introduce a participation bias.…”

Section: Introductionmentioning

confidence: 99%

Inclusion of authorized deception in the informed consent process does not affect the magnitude of the placebo effect for experimentally induced pain

Martínez-Cutillas¹,

Katz²

2010

Pain

View full text Add to dashboard Cite

The ethics of placebo research have been of paramount concern since the discovery of the phenomenon. To address these ethical concerns, Miller and colleagues (PLoS Med 2005 Sep;2(9):e262, 0853-0859) propose an altemate approach to placebo research, called "authorized deception", in which participants are alerted of the use of deception in the research prior to study enrollment and thus knowingly permit its use if they decide to participate. The present study sought to investigate the authorized deception methodology in experimentally induced placebo analgesia. The participants were randomly assigned to an authorized deception or non-authorized deception group. A commonly used protocol was employed wherein heat pain stimulation was surreptitiously lowered following the application of a placebo cream during a series of conditioning trials and the magnitude of the placebo effect was subsequently assessed in test trials for which the stimulus intensity was the same for both the placebo and control creams. Authorized deception did not have any negative impact on the magnitude ofthe placebo effect, recruitment and retention of participants, nor did it result in any significant psychological harm. The majority of participants who received this form of consent preferred it to the traditional approach in which the participants are not alerted to the presence of deception. These findings suggest that the use of authorized deception is a viable and ethically preferable alternative consent process for laboratory-based studies on placebo analgesia. Further studies are needed to examine the effect of authorized deception in clinical trials and other placebo research within a clinical setting.

show abstract

“…First, prospective subjects can be given an "authorized deception" disclosure that alerts them to the use of deception in the research without informing them about the specific nature of that deception (Wendler and Miller, 2004). In an authorized deception disclosure, prospective subjects are informed that some statements about the research are not accurate or misleading; that this use of deception is necessary for the scientific validity of the research and has been approved by a research ethics committee; and that they will receive an accurate account of the research after completing the study.…”

Section: Promoting Autonomy In Deceptive Researchmentioning

confidence: 99%

“…Despite this scientific rationale, deception in the experimental design of human subjects research is ethically controversial (Wendler and Miller, 2004). Nevertheless, it remains common in psychological research and is also frequently used in neuroscience.…”

mentioning

confidence: 99%