Decidua in human implantation

Loke, Y.W.; King, Ashley; Burrows, Tanya D.

doi:10.1093/humrep/10.suppl_2.14

Cited by 152 publications

(92 citation statements)

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“…Blastocyst implantation is a dynamic process, involving embryo apposition, attachment to the maternal endometrial epithelium, and invasion into the endometrial stroma [1]. With in vitro fertilization (IVF), implantation failure can occur due to several factors [2], including embryonic defects such as chromosomal abnormalities, which are the most common cause of implantation failure [3,4].…”

Section: Challenges and Approaches In Studying The Process Of Human Imentioning

confidence: 99%

Uterine receptivity to human embryonic implantation: Histology, biomarkers, and transcriptomics

Aghajanova¹,

Hamilton²,

Giudice³

2008

Seminars in Cell & Developmental Biology

140

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Embryonic implantation is a dynamic process of paracrine interactions between the maternal compartment and the conceptus and involves a receptive endometrium and a developmentally competent blastocyst. Herein, we review histology, clinical approaches, and the promise of transcriptomics in elucidating mechanisms underlying implantation and development of biomarkers of uterine receptivity -with an eye to diagnose and treat implantation-based disorders of miscarriage, fetal growth restriction, pre-eclampsia, and infertility.Keywords human implantation; endometrium; microarray; blastocyst Challenges and approaches in studying the process of human implantation Clinical implicationsSuccessful embryo implantation is a crucial event in natural and assisted human reproduction. Blastocyst implantation is a dynamic process, involving embryo apposition, attachment to the maternal endometrial epithelium, and invasion into the endometrial stroma [1]. With in vitro fertilization (IVF), implantation failure can occur due to several factors [2], including embryonic defects such as chromosomal abnormalities, which are the most common cause of implantation failure [3,4]. Another widely acknowledged barrier to successful blastocyst implantation and, therefore, successful treatment of infertile women with implantation failure, is an inappropriately developed endometrium. It is well established that embryos cannot implant in a poorly matured endometrium [5], and this may be responsible for low implantation rates with transfer of "good quality" embryos. The success of embryonic implantation further relies upon cross-talk between the embryo and a receptive endometrium [5]. Optimization of IVF results are important for many reasons, and achieving optimal implantation is even more important in the setting of single embryo transfer, a common practice aimed to avoid multiple pregnancies.Corresponding author: Linda C. Giudice, MD, PhD, MSc, Professor and Chair, Department of Obstetrics, Gynecology and Reproductive Sciences, The Robert B. Jaffe, MD Endowed Professor in the Reproductive Sciences, University of California, San Francisco, 505 Parnassus Ave., M1496, Box 0132, San Francisco, CA 94143-0132, Tel: +1 4154762564, Fax: +1 415476181, giudice@obgyn.ucsf.edu. Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. The implantation window and challenges of studying it NIH Public AccessThe endometrium is receptive to blastocyst implantation during a spatially and temporally restricted "window", when the luminal epithelium is favorable for blastocyst implantation even in the absence of an implanting ...

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Section: Challenges and Approaches In Studying The Process Of Human Imentioning

confidence: 99%

Uterine receptivity to human embryonic implantation: Histology, biomarkers, and transcriptomics

Aghajanova¹,

Hamilton²,

Giudice³

2008

Seminars in Cell & Developmental Biology

140

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“…Trophoblastic infiltration of the arterial wall is accompanied by dramatic structural changes of the vascular media such as the lost of elastic fibres and smooth muscle cells which are usely attributed to proteolytic activities of the invasive endovascular cells (2). Hence, EVCT are directly involved in the anchoring of chorionic villi in the uterus, and in the essential remodeling of the uterine arterioles to provide adequate supply of maternal blood to the intervillous space necessary for fetal growth (3)(4)(5)(6)(7).…”

Section: Introductionmentioning

confidence: 99%

Human Chorionic Gonadotropin Expression in Human Trophoblasts from Early Placenta: Comparative Study Between Villous and Extravillous Trophoblastic Cells

Handschuh¹,

Gadrey²,

Tsatsaris³

et al. 2007

Placenta

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Human trophoblast differentiates into two pathways: extravillous cytotrophoblasts (EVCT) that invade the uterus wall and villous cytotrophoblasts (VCT) that fuse to form the syncytiotrophoblast (ST) involved in placental exchanges and endocrine function. It is established that hCG is produced and secreted by the ST into the maternal compartment where it plays a key endocrine role and stimulates ST formation in an autocrine manner. Herein, we investigated hCG expression in early placentas by immunohistochemistry using different antibodies. We then compared hCG secretion by primary cultures of VCT and EVCT isolated from the same first trimester human chorionic villi. In situ hCG was immunodetected in EVCT all along their invasive differentiating pathway excepted in cells near the stromal core of the proximal column. hCG expression was confirmed in vitro by immunocytochemistry and hCG secretion quantified in cell supernatants. Interestingly, whereas hCG secretion increased during VCT differentiation into ST (from 60 to 350 UI/L/µg DNA), EVCT secretion remained constant and at a high level during the same culture period (160 UI/L/µg DNA). Our data demonstrated that in addition to the ST, invasive EVCT also expressed and secreted high levels of hCG, suggesting a specific paracrine and/or autocrine role for hCG from EVCT origin.3

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“…The cytotrophoblast stem cells undergo either the villous or the extravillous pathway of differentiation. In the villous pathway, cytotrophoblasts fuse to form multinucleated syncytiotrophoblasts or aggregate to form anchoring villous trophoblasts, which give rise to extravillous trophoblasts (Loke et al, 1995). Villous trophoblasts cover the chorionic villi, creating the placental-blood barrier, involved in gas exchange and nutrient supply between the mother and the fetus.…”

Section: Introductionmentioning

confidence: 99%

“…Villous trophoblasts cover the chorionic villi, creating the placental-blood barrier, involved in gas exchange and nutrient supply between the mother and the fetus. Extravillous trophoblasts deeply invade the uterine connective tissue, degrading the extracellular matrix (interstitial route), and place themselves between decidual and myometrial cells and then invade the uterine spiral arteries (endovascular route) (Loke et al, 1995). At this stage the extravillous trophoblasts remodel the maternal spiral arteries, replacing smooth muscle and endothelial cells forming vessels with a larger diameter, and increase blood flow and reduce vascular resistance, making these maternal vessels independent of maternal vasoconstriction.…”

Section: Introductionmentioning

confidence: 99%

Neuropeptide Y reduces migration capacity of human choriocarcinomacell line by altering oxidative/antioxidative status

Matić¹,

Paunović²,

Ognjanovic³

et al. 2017

Turk J Biol

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H 2 O 2 ) and molecules of the antioxidant defense system (reduced glutathione and oxidized glutathione), while the levels of intracellular nitrites (indicators of NO) and cell migration index were significantly decreased in trophoblast cells treated with NPY (both at 24 h and 72 h of exposure) compared to the control cells. These results suggest that NPY may significantly contribute to reduced migration capacity of trophoblast cells by generating oxidative stress and reducing the bioavailability of NO.

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Decidua in human implantation

Cited by 152 publications

References 0 publications

Uterine receptivity to human embryonic implantation: Histology, biomarkers, and transcriptomics

Uterine receptivity to human embryonic implantation: Histology, biomarkers, and transcriptomics

Human Chorionic Gonadotropin Expression in Human Trophoblasts from Early Placenta: Comparative Study Between Villous and Extravillous Trophoblastic Cells

Neuropeptide Y reduces migration capacity of human choriocarcinomacell line by altering oxidative/antioxidative status

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