Decidual stromal cell‐derived <scp>PGE</scp><sub>2</sub> regulates macrophage responses to microbial threat

Rogers, Lisa M.; Anders, Anjali; Doster, Ryan S.; Gill, Elizabeth; Gnecco, Juan; Holley, Jacob; Randis, Tara M.; Ratner, Adam J.; Gaddy, Jennifer A.; Osteen, Kevin G.; Aronoff, David M.

doi:10.1111/aji.13032

Cited by 32 publications

(40 citation statements)

References 96 publications

(188 reference statements)

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“…In in vitro studies, decidual stromal cells exerted a powerful inhibitory effect on NK cell proliferation and DC differentiation (259). Decidual stromal cells can also interact with macrophages in regulating the immune response against pathogens through the release of PGE2 and IL-8 (260,261). Moreover, decidual stromal cells also regulate the interplay between pro-inflammatory cytokines and the reproductive endocrine system that may modulate inflammation-mediated preterm birth (262).…”

Section: Decidua Stroma Cellsmentioning

confidence: 99%

Immunobiology of Acute Chorioamnionitis

2020

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Acute chorioamnionitis is characterized by neutrophilic infiltration and inflammation at the maternal fetal interface. It is a relatively common complication of pregnancy and can have devastating consequences including preterm labor, maternal infections, fetal infection/inflammation, fetal lung, brain, and gastrointestinal tract injury. In this review, we will discuss current understanding of the pathogenesis, immunobiology, and mechanisms of this condition. Most commonly, acute chorioamnionitis is a result of ascending infection with relatively low-virulence organisms such as the Ureaplasma species. Furthermore, recent vaginal microbiome studies suggest that there is a link between vaginal dysbiosis, vaginal inflammation, and ascending infection. Although less common, microorganisms invading the maternal-fetal interface via hematogenous route (e.g., Zika virus, Cytomegalovirus, and Listeria) can cause placental villitis and severe fetal inflammation and injury. We will provide an overview of the knowledge gleaned from different animal models of acute chorioamnionitis and the role of different immune cells in different maternal-fetal compartments. Lastly, we will discuss how infectious agents can break the maternal tolerance of fetal allograft during pregnancy and highlight the novel future therapeutic approaches.

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Section: Decidua Stroma Cellsmentioning

confidence: 99%

Immunobiology of Acute Chorioamnionitis

2020

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“…The complexity of these microfluidic environments can vary 69 : from simple microfluidic chambers with one cell type, 75 to multicellular setups that recapitulate parenchymalvascular interactions, 76,77 to entire organ systems. 72,78 Reproductive MPS are of particular interest because of their potential to recapitulate the complex hormonal feedback and feedforward signals between reproductive tissues and organs.…”

Section: Dynamic Microfluidics: Interactions Between Reproductive Tismentioning

confidence: 99%

“…72,78 Reproductive MPS are of particular interest because of their potential to recapitulate the complex hormonal feedback and feedforward signals between reproductive tissues and organs. 70,71 As a result, MPS of different reproductive organs, including the endometrium, [75][76][77] placenta, [79][80][81] oviduct, 82,83 amnion and fetal membrane, [84][85][86] as well as a multiorgan microfluidic framework of the female reproductive tract, 78 have been built.…”

Section: Dynamic Microfluidics: Interactions Between Reproductive Tismentioning

confidence: 99%

“…The design uses two orthogonal microfluidic chambers separated by a semipermeable membrane. [75][76][77] Human primary umbilical vein endothelial cells were subjected to a dynamic flow and cocultured with a static culture of human primary endometrial stromal cells. The importance of shear stress was demonstrated by the polarization of the endothelial cells.…”

Section: Dynamic Microfluidics: Interactions Between Reproductive Tismentioning

confidence: 99%

“…77 A single-chamber version of this model was also used to recapitulate host-microbial interactions in vitro and elucidate the role of the decidual stromal cells on macrophages. 75 The main advantage of these microfluidic systems is their ability to reproduce physiologic conditions, such as dynamic flow, shear stress, and cell-to-cell communication. However, these models are limited because they contain only certain cell types and cell lines cultured in two dimensions, and they do not account for other important organs that can influence the endometrium.…”

Section: Dynamic Microfluidics: Interactions Between Reproductive Tismentioning

confidence: 99%

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Microphysiological Modeling of the Human Endometrium

Campo

Murphy

Yıldız

et al. 2020

Tissue Engineering Part A

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Since the beginning of clinical medicine, the human uterus has held the fascination of clinicians and researchers, given its critical role in the reproduction of our species. The endometrial lining provides residence for the embryo; however, this symbiotic interaction can be disrupted if the timing is not correct and the endometrium is not receptive. Diseases associated with the endometrium interfere with the reproductive process and cause a life-altering burden of pain and even death. With the advancement of technologies and new insights into the biology of the endometrium, much has been uncovered about the dynamic and essential changes that need to occur for normal endometrial function, as well as aberrations that lead to endometrial diseases. As expected, the more that is uncovered, the more the complexity of the endometrium is made evident. In this study, we bring together three areas of scientific advancement that remain in their infancy, but which together have the potential to mirror this complexity and enable understanding. Studies on induced pluripotent stem cells, threedimensional tissue mimics, and microfluidic culture platforms will be reviewed with a focus on the endometrium. These unconventional approaches will provide new perspectives and appreciation for the elegance and complexity of the endometrium.

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Emerging role of toll-like receptors signaling and its regulators in preterm birth: a narrative review

Yao

Yan

et al. 2022

Arch Gynecol Obstet

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Decidual stromal cell‐derived PGE₂ regulates macrophage responses to microbial threat

Abstract: These data suggest key roles for decidual stromal cells in modulating tissue responses to microbial threat through release of PGE .

Cited by 32 publications

References 96 publications

Immunobiology of Acute Chorioamnionitis

Immunobiology of Acute Chorioamnionitis

Microphysiological Modeling of the Human Endometrium

Emerging role of toll-like receptors signaling and its regulators in preterm birth: a narrative review

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Decidual stromal cell‐derived PGE2 regulates macrophage responses to microbial threat

Abstract: These data suggest key roles for decidual stromal cells in modulating tissue responses to microbial threat through release of PGE .

Cited by 32 publications

References 96 publications

Immunobiology of Acute Chorioamnionitis

Immunobiology of Acute Chorioamnionitis

Microphysiological Modeling of the Human Endometrium

Emerging role of toll-like receptors signaling and its regulators in preterm birth: a narrative review

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Product

Resources

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Decidual stromal cell‐derived PGE₂ regulates macrophage responses to microbial threat