Deciduoid mesothelioma: A rare, distinct entity with unusual features

Deciduoid mesothelioma: report of 21 cases with review of the literature

“…In the five reported cases in which it was indicated that the tumor had high mitotic activity (45 mitoses per 10 HPF), including the presence of atypical mitoses, the patients had a shorter survival (5-11 months, mean 8); 2,3,5 while in five of those cases in which it was stated that the mitotic figures were rare or uncommon (o3 per 10 HPF), two patients died of disease 17 and 30 months after diagnosis, respectively, 14 and three were alive at the time of publication 12, 20, and 32 months after diagnosis, respectively. 9,12,18 These findings are comparable to those of the present investigation in that those tumors with a high number of mitoses (45 per 10 HPF), a decrease in cell cohesion, highly atypical nuclei that vary in their size and often contain cytoplasmic inclusions, and large, sometimes multiple nucleoli tend to behave in a more aggressive manner than those in which the mitotic activity was low, the cells were more uniform and more cohesive, and the nuclei exhibited less atypia. In the present series, 7 of the cases (Cases 1, 2, 6, 7, 8, 13, and 15) that were considered to belong to the first group died of disease 4-17 months (mean, 7 months) after diagnosis, while 9 of the 10 cases ( Cases 5,12,14,16,17,18,19,20, and 21) that were considered to belong to the second group died of disease 6-62 months (mean, 22 months) after diagnosis and the remaining patient (Case 4) was alive 25 months following diagnosis (Table 3).…”

“…9,12,18 These findings are comparable to those of the present investigation in that those tumors with a high number of mitoses (45 per 10 HPF), a decrease in cell cohesion, highly atypical nuclei that vary in their size and often contain cytoplasmic inclusions, and large, sometimes multiple nucleoli tend to behave in a more aggressive manner than those in which the mitotic activity was low, the cells were more uniform and more cohesive, and the nuclei exhibited less atypia. In the present series, 7 of the cases (Cases 1, 2, 6, 7, 8, 13, and 15) that were considered to belong to the first group died of disease 4-17 months (mean, 7 months) after diagnosis, while 9 of the 10 cases ( Cases 5,12,14,16,17,18,19,20, and 21) that were considered to belong to the second group died of disease 6-62 months (mean, 22 months) after diagnosis and the remaining patient (Case 4) was alive 25 months following diagnosis (Table 3). These observations appear to be in agreement with a recent investigation that indicated that nuclear grading based on nuclear features and mitotic count can provide prognostic information in epithelioid diffuse malignant pleural mesothelioma.…”

“…5 In these reports, however, it was demonstrated that mesotheliomas with deciduoid features can also originate in the pleura, occur in elderly men, and be associated with asbestos exposure. Since then, several other cases, mostly individual case reports, have been published [6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24] (Table 1). Although patient survival in many of the published cases has been short and limited to a few months after diagnosis, thus suggesting that deciduoid mesotheliomas have an aggressive clinical course, patients with long survival …”

Granulocyte-colony stimulating factor- and interleukin 6-producing diffuse deciduoid peritoneal mesothelioma

“…Although the original publication reported that malignant deciduoid mesothelioma arises most commonly in the peritoneum of young female cases, recent publications revealed that it may also occur in the pleura or pericardium of elderly male and female subjects, with or without asbestos exposure. [3][4][5][6][7][8][9][10][11][12] The pronounced anaplastic morphology of deciduoid mesothelioma requires differential diagnosis from other malignant tumors.…”

Comparative genomic hybridisation in malignant deciduoid mesothelioma

“…6 7 It has since been observed also in the pleura and pericardium, in both sexes and at all ages, with these forms having a worse prognosis. [8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24] Only a few studies have been conducted to identify the molecular changes responsible for the carcinogenesis of mesothelioma. [25][26][27][28][29][30][31][32][33][34][35][36][37][38][39][40] Comparative genomic hybridisation (CGH) is currently the most widely used technique for genetic analysis of mesothelioma because it enables the analysis of wide genomic amplifications, gains and losses (deletions) in the tumour cells in a single experiment.…”