2015
DOI: 10.1096/fasebj.29.1_supplement.721.19
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Deciphering Differential Distortion of Purine Substrates by Human and Plasmodium falciparum HGPRT

Abstract: Enzymes of the salvage pathway are essential to understanding the biochemistry of parasitic protozoa. These parasites lack de novo pathway for nucleotide synthesis and depend solely on purines salvage from their host. Hypoxanthine guanine phosphoribosyltransferase (HGPRT) from Plasmodium falciparum has long been regarded as a potential therapeutic target. Although structurally homologous to human enzyme, PfHGPRT differs from human (h) HGPRT in its expanded substrate specificity and activity towards common subs… Show more

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