Deciphering genetic interactions between ALS genes using<i>C. elegans</i>

Therrien, Martine; Parker, J. Alex

doi:10.4161/worm.29047

Cited by 4 publications

(3 citation statements)

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“…It is worth of remembering that other non-mammalian animal models have also been integrated to the study of MN degenerative diseases: invertebrates such as the worm (Coenorabditis elegans) (Sleigh et al, 2011;Therrien and Parker, 2014) and the fruit fly (Drosophila melanogaster) (Wang et al, 2011;Cherry et al, 2013) and vertebrates (the zebrafish, Danio rerio) (Babin et al, 2014).…”

Section: Discussionmentioning

confidence: 99%

The combination of limb-bud removal and in ovo electroporation techniques: A new powerful method to study gene function in motoneurons undergoing lesion-induced cell death

Padula¹,

Koszinowski²,

Krieglstein³

2015

Journal of Neuroscience Methods

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Section: Discussionmentioning

confidence: 99%

The combination of limb-bud removal and in ovo electroporation techniques: A new powerful method to study gene function in motoneurons undergoing lesion-induced cell death

Padula¹,

Koszinowski²,

Krieglstein³

2015

Journal of Neuroscience Methods

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“…This suggests that the genetic network is composed of many genes involved in the pathogenesis of ALS, where ALS-related genes interact each other based on the study in this C. elegans model. The model development of genetic networks in C. elegans is helpful for understanding the synergistic toxic mechanisms of ALS-related genes in neuronal loss in ALS (Therrien and Parker, 2014a ).…”

Section: C Elegans Modelsmentioning

confidence: 99%

Invertebrate genetic models of amyotrophic lateral sclerosis

Zhou,

2024

Front. Mol. Neurosci.

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Amyotrophic lateral sclerosis (ALS) is a common adult-onset neurodegenerative disease characterized by the progressive death of motor neurons in the cerebral cortex, brain stem, and spinal cord. The exact mechanisms underlying the pathogenesis of ALS remain unclear. The current consensus regarding the pathogenesis of ALS suggests that the interaction between genetic susceptibility and harmful environmental factors is a promising cause of ALS onset. The investigation of putative harmful environmental factors has been the subject of several ongoing studies, but the use of transgenic animal models to study ALS has provided valuable information on the onset of ALS. Here, we review the current common invertebrate genetic models used to study the pathology, pathophysiology, and pathogenesis of ALS. The considerations of the usage, advantages, disadvantages, costs, and availability of each invertebrate model will also be discussed.

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“…Its genome contains 60-80% genes that are homologous to humans with 42% of them comprising diseasecausing genes [34,35]. The ease of modeling genetics is one of the greatest assets of C. elegans, which allows for the use of diverse genetic manipulation methods [36,37] and the deciphering of genetic interactions [32,38]. In this chapter, we list the most recent approaches and findings in C. elegans regarding the most frequently occurring ALS mutations (Table 1).…”

Section: Caenorhabditis Elegansmentioning

confidence: 99%