Deciphering the antidepressant effects of Rosa damascena essential oil mediated through the serotonergic synapse signaling pathway

Xia, Ning; Wang, Jie; Guo, Qiuting; Duan, Jiawei; Wang, Xuan; Zhou, Peijie; Li, Jinkai; Tang, Tiantian; Li, Taotao; Li, Huiting; Wu, Zhenfeng; Yang, Ming; Sun, Jing; Guo, Dongyan; Chang, Xing; Zhang, Xiaofei

doi:10.1016/j.jep.2024.118007

Cited by 3 publications

(1 citation statement)

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“…Transdermal administration is a common mode of essential oil delivery, which has the advantages of high bioavailability, low adverse effects and good patient compliance. 40 , 41 Li et al 42 human in the treatment of DNCB-induced atopic dermatitis with rosemary EOs, observed improved skin lesions in mice coated with rosemary essential oil, a significant reduction in serum IL-6, TNF-α, as well as in skin tissues with decreased expression of p-JAK1, CD4+ cells, IL-4, p-P65/P65, p-STAT3/STAT3 protein expression was reduced. Pires F Q et al 43 utilized HP-β-CD and nanostructured lipid carrier (NLC) for encapsulation of EOs, which solved the problem of volatility and solubility of EOs while achieving the control of the drug release rate and improved the utilization of EOs for transdermal administration.…”

Section: Routes Of Essential Oils Administrationmentioning

confidence: 98%

Therapeutic Potential of Essential Oils Against Ulcerative Colitis: A Review

Li,

Zhang,

Luan

et al. 2024

JIR

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Ulcerative colitis (UC) is a chronic non-sp ecific inflammatory disease of the colorectal mucosa. Researchers have associated UC onset with familial genetics, lifestyle behavior, inflammatory immune factors, intestinal microbiota, and the integrity of the intestinal mucosal barrier. The primary therapeutic interventions for UC consist of pharmacological management to control inflammation and promote mucosal healing and surgical interventions. The available drugs effectively control and decelerate the progression of UC in most patients; nonetheless, their long-term administration can exert adverse effects and influence the therapeutic effect. Plant essential oils (EOs) refer to a group of hydrophobic aromatic volatile substances. EOs have garnered considerable attention in both domestic and international research because of their anti-inflammatory, antibacterial, and antioxidant properties. They include peppermint, peppercorns, rosemary, and lavender, among others. Researchers have investigated the role of EOs in medicine and have elucidated their potential to mitigate the detrimental effects of UC through their anti-inflammatory, antioxidant, antidepressant, and anti-insomnia properties as well as their ability to regulate the intestinal flora. Furthermore, EOs exert minimal toxic adverse effects, further enhancing their appeal for therapeutic applications. However, these speculations are based on theoretical experiments, thereby warranting more clinical studies to confirm their effectiveness and safety. In this article, we aim to provide an overview of the advancements in utilizing natural medicine EOs for UC prevention and treatment. We will explore the potential pathogenesis of UC and examine the role of EOs therapy in basic research, quality stability, and management specification of inadequate EOs for UC treatment. We intend to offer novel insights into the use of EOs in UC prevention and management.

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