Deciphering the Biophysical Properties of Ion Channel Gating Pores by Coumarin–Benzodiazepine Hybrid Derivatives: Selective AMPA Receptor Antagonists

Qneibi, Mohammad; Hawash, Mohammed; Gümüş, Mehmet; Çapan, İrfan; Sert, Yusuf; Bdir, Sosana; Koca, İrfan; Bdair, Mohammad

doi:10.1007/s12035-023-03871-1

Mol Neurobiol

2023

DOI: 10.1007/s12035-023-03871-1

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Deciphering the Biophysical Properties of Ion Channel Gating Pores by Coumarin–Benzodiazepine Hybrid Derivatives: Selective AMPA Receptor Antagonists

Mohammad Qneibi,

Mohammed Hawash,

Mehmet Gümüş

et al.

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2024

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Cited by 7 publications

References 48 publications

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Reaction Course Dependent Regiospecific Transformation of 4‐Azido‐Coumarin into Coumarin C3‐C4 Fused Imidazole and 5‐Substituted‐1,4‐Benzodiazepine Scaffolds

Nagamani,

Kamaraj

2024

Eur J Org Chem

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Herein, we report an efficient route for coumarin C3‐C4 fused imidazole scaffolds via indium chloride‐mediated single‐step transformation of 4‐azido‐coumarin with amines/aldehydes and coumarin C3‐C4 fused 5‐substituted‐1,4‐benzodiazepine scaffolds with 1,2‐azide‐nitrogen migration through two‐step sequential synthesis via the transitory intermediacy of 2,3‐bridged‐2H‐azirine. A plausible mechanistic pathway has been proposed from the control/entrapment experiments and 1H‐NMR studies. This protocol provides the reaction condition‐dependent product selectivity, structural diversification, and excellent yields.

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Reaction Course Dependent Regiospecific Transformation of 4‐Azido‐Coumarin into Coumarin C3‐C4 Fused Imidazole and 5‐Substituted‐1,4‐Benzodiazepine Scaffolds

Nagamani,

Kamaraj

2024

Eur J Org Chem

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Enabling oral novel Taxanes-based Chemotherapy with Lipophilic prodrug Self-nanoemulsifying drug delivery system

Miao,

Liu,

Xiao

et al. 2024

Bioorganic Chemistry

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Synthesis, characterization, and evaluation of pyrimidinone-linked thiazoles: DFT analysis, molecular docking, corrosion inhibition, and bioactivity studies

Venu prasad,

Kallauraya,

Bhat

et al. 2024

Heliyon

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Deciphering the Biophysical Properties of Ion Channel Gating Pores by Coumarin–Benzodiazepine Hybrid Derivatives: Selective AMPA Receptor Antagonists

Cited by 7 publications

References 48 publications

Reaction Course Dependent Regiospecific Transformation of 4‐Azido‐Coumarin into Coumarin C3‐C4 Fused Imidazole and 5‐Substituted‐1,4‐Benzodiazepine Scaffolds

Reaction Course Dependent Regiospecific Transformation of 4‐Azido‐Coumarin into Coumarin C3‐C4 Fused Imidazole and 5‐Substituted‐1,4‐Benzodiazepine Scaffolds

Enabling oral novel Taxanes-based Chemotherapy with Lipophilic prodrug Self-nanoemulsifying drug delivery system

Synthesis, characterization, and evaluation of pyrimidinone-linked thiazoles: DFT analysis, molecular docking, corrosion inhibition, and bioactivity studies

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