Deciphering the impacts of gut and tissue microbiome on human cancers

Godbole, Mukul S.; Singh, Vishal

doi:10.1002/cnr2.1924

Cited by 1 publication

(1 citation statement)

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“…Moreover, there was minimal indication that pleiotropy was connected to the relationship in horizontal pleiotropy studies ( P =0.816) ( Table S1 ). Breast cancer can occur in men as well as women and is a malignant tumor originating from the mammary epithelium or ductal epithelium, primarily due to abnormal mammary cell growth, and it is one of the most heterogeneous and frequently diagnosed cancers among women worldwide 28 . The breast cancer GWAS data includes 15,748 cancer patients and 18,084 controls, with 13,011,123 SNPs included (Table 1 ).…”

Section: Resultsmentioning

confidence: 99%

Mendelian randomization combined with multi-omics explores the relationship between heart failure and cancer

Sun,

Mei,

et al. 2024

J. Cancer

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Background : Whether there is an association between HF (HF) and cancer has not been conclusively established, and it is not clear whether patients with cancer can share similar hospitalization strategies and outcomes with patients with HF. Methods: Genome-wide association summary statistics were performed using a two-sample Mendelian randomization (MR) method for HF patients and cancer patients from the GWAS directory, with co-localization and Summary Data-Based Mendelian Randomization (SMR) analyses to identify HF-associated genes, and transcriptomic analyses to analyze the roles of these genes in the clinical diagnosis and targeted therapies of multiple cancer types. Results: Two-sample MR analysis showed that increased risk of HF was associated with decreased risk of cervical, brain, breast, colorectal, lung, and skin cancers, and co-localization combined with SMR analysis identified ABO and SURF1 as HF-associated genes, and transcriptomic analyses showed that ABO is a risk factor for HF and a protective factor against cancer, whereas SURF1 is a protective factor against HF and a protective factor against cancer. Conclusion: There was no causal relationship between heart failure and cancers (Cervical, brain, breast, colorectal, lung and skin cancers) risk factors, however there was a trend toward a negative causal relationship between heart failure and cancers (Cervical, brain, breast, colorectal, lung and skin cancers) occurrence.

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Section: Resultsmentioning

confidence: 99%