Deciphering the molecular and clinical characteristics of TREM2, HCST, and TYROBP in cancer immunity: A comprehensive pan-cancer study

Zheng, Piao; Tan, Yejun; Liu, Qing; Wu, Changwu; Kang, Jing; Liang, Shuzhi; Zhu, Lemei; Yan, Kuipo; Zeng, Lingfeng; Chen, Bolin

doi:10.1016/j.heliyon.2024.e26993

Heliyon

2024

DOI: 10.1016/j.heliyon.2024.e26993

|View full text |Cite

Deciphering the molecular and clinical characteristics of TREM2, HCST, and TYROBP in cancer immunity: A comprehensive pan-cancer study

Piao Zheng,

Yejun Tan,

Qing Liu

et al.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2024

Publication Types

Select...

Article5

Relationship

Self Cite0

Independent5

Authors

Journals

Cited by 5 publications

References 44 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Therapeutic targeting of cGAS–STING pathway in lung cancer

Wang,

Xing

2024

Cell Biology International

View full text Add to dashboard Cite

The presence of DNA in the cytosol triggers a protective response from the innate immune system. Cyclic GMP‐AMP synthase‐stimulator of interferon genes (cGAS–STING) is an essential cytosolic DNA sensor that triggers a potent innate immune response. As a result of this signaling cascade reaction, type I interferon and other immune mediators activate an immune response. The cGAS–STING pathway has great anticancer immunity‐boosting potential since it produces type I interferons. The detection of double‐stranded DNA (dsDNA) in response to various stimuli initiates a protective host's cGAS–STING signals. So, it is clear that a substantial relationship is expected between cancer biotherapy and the functioning of the cGAS–STING pathway. Several STING agonists with promising outcomes have been created for preclinical cancer therapy research. Notably, immunotherapy has dramatically extended patient survival and radically altered the course of lung cancer treatment, particularly in more advanced instances. However, this method is still ineffective for a large number of lung cancer patients. cGAS–STING can overcome resistance and boost anticancer immunity by stimulating the activity of many pro‐inflammatory mediators, augmenting dendritic cell cross‐presentation, and initiating a tumor‐specific CD8+ T cell response. This review aims to present the most recent results on the functionality of the cGAS–STING pathway in cancer progression and its potential as an immunotherapy target, with a focus on lung cancer.

show abstract

Therapeutic targeting of cGAS–STING pathway in lung cancer

Wang,

Xing

2024

Cell Biology International

View full text Add to dashboard Cite

show abstract

Targeting HSP90 in Gynecologic Cancer: Molecular Mechanisms and Therapeutic Approaches

Min,

Li,

Liang

et al. 2024

Cell Biochem Biophys

View full text Add to dashboard Cite

Hydrogel based on M1 macrophage lysate and alginate loading with oxaliplatin for effective immunomodulation to inhibit melanoma progression, recurrence and metastasis

Li,

Jiang,

Yan

et al. 2024

International Journal of Biological Macromolecules

View full text Add to dashboard Cite

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Deciphering the molecular and clinical characteristics of TREM2, HCST, and TYROBP in cancer immunity: A comprehensive pan-cancer study

Cited by 5 publications

References 44 publications

Therapeutic targeting of cGAS–STING pathway in lung cancer

Therapeutic targeting of cGAS–STING pathway in lung cancer

Targeting HSP90 in Gynecologic Cancer: Molecular Mechanisms and Therapeutic Approaches

Hydrogel based on M1 macrophage lysate and alginate loading with oxaliplatin for effective immunomodulation to inhibit melanoma progression, recurrence and metastasis

Contact Info

Product

Resources

About