Deciphering the molecular mechanism and crosstalk between Parkinson's disease and breast cancer through multi-omics and drug repurposing approach

Advani, Dia; Kumar, Pravir

doi:10.1016/j.npep.2022.102283

Cited by 8 publications

(1 citation statement)

References 66 publications

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“…The top 10 genes (APOE, PSEN1, INS, IL6, SQSTM1, SP1, HTT, LEP, HSPA4, and BDNF) comprise high-priority candidate genes for inverse comorbidity. The role in inverse comorbidity of cancer and Parkinson's disease/Alzheimer's disease was shown for APOE, APOC1, SQSTM1, PSEN1, and SP1 [22,[28][29][30]. However, this is the first study to report their likely role in the dystropy of cancer and HD.…”

Section: Discussionmentioning

confidence: 99%

Apoptosis Genes as a Key to Identification of Inverse Comorbidity of Huntington’s Disease and Cancer

Bragina

Gomboeva

Saik

et al. 2023

IJMS

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Cancer and neurodegenerative disorders present overwhelming challenges for healthcare worldwide. Epidemiological studies showed a decrease in cancer rates in patients with neurodegenerative disorders, including the Huntington disease (HD). Apoptosis is one of the most important processes for both cancer and neurodegeneration. We suggest that genes closely connected with apoptosis and associated with HD may affect carcinogenesis. We applied reconstruction and analysis of gene networks associated with HD and apoptosis and identified potentially important genes for inverse comorbidity of cancer and HD. The top 10 high-priority candidate genes included APOE, PSEN1, INS, IL6, SQSTM1, SP1, HTT, LEP, HSPA4, and BDNF. Functional analysis of these genes was carried out using gene ontology and KEGG pathways. By exploring genome-wide association study results, we identified genes associated with neurodegenerative and oncological disorders, as well as their endophenotypes and risk factors. We used publicly available datasets of HD and breast and prostate cancers to analyze the expression of the identified genes. Functional modules of these genes were characterized according to disease-specific tissues. This integrative approach revealed that these genes predominantly exert similar functions in different tissues. Apoptosis along with lipid metabolism dysregulation and cell homeostasis maintenance in the response to environmental stimulus and drugs are likely key processes in inverse comorbidity of cancer in patients with HD. Overall, the identified genes represent the promising targets for studying molecular relations of cancer and HD.

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Section: Discussionmentioning

confidence: 99%