Deciphering the molecular pathway of an asiaticosiderich fraction of Centella asiatica as an anti-melanogenesis agent
Agustina Setiawati,
Brigitta Amanda Maharani,
Putu Addelia Puspa Sari
et al.
Abstract:Introduction: Melanin is a defense against UV radiation; however, it leads to significant cosmetic issues mainly melasma and hyperpigmentation. This study evaluated the potential effect of ethyl acetate (EtOAc) fraction of Centella asiatica extract in vitro inhibition activity against tyrosinase (TYR). Bioinformatics and in silico experiments were also employed to predict molecular pathways of asiaticoside, as the main active compound. Methods: Centella asiatica was extracted with ethanol and then fractionated… Show more
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