Deciphering the relative importance of genetic elements in hypervirulent Klebsiella pneumoniae to guide countermeasure development

Russo, Thomas A.; Carlino-MacDonald, Ulrike; Drayer, Zachary J.; Davies, Connor J.; Alvarado, Cassandra L.; Hutson, Alan; Luo, Ting L.; Martin, Melissa J.; McGann, Patrick T.; Lebreton, Francois

doi:10.1016/j.ebiom.2024.105302

eBioMedicine

2024

DOI: 10.1016/j.ebiom.2024.105302

|View full text |Cite

Deciphering the relative importance of genetic elements in hypervirulent Klebsiella pneumoniae to guide countermeasure development

Thomas A. Russo,

Ulrike Carlino-MacDonald,

Zachary J. Drayer

et al.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2024

2025

Publication Types

Select...

Article3

Relationship

Self Cite0

Independent3

Authors

Journals

Cited by 3 publications

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

What defines hypervirulent Klebsiella pneumoniae?

Stanton,

Wyres

2024

eBioMedicine

View full text Add to dashboard Cite

What defines hypervirulent Klebsiella pneumoniae?

Stanton,

Wyres

2024

eBioMedicine

View full text Add to dashboard Cite

A Step Forward in Hypervirulent Klebsiella pneumoniae Diagnostics

Russo,

Lebreton,

McGann

2025

Emerg. Infect. Dis.

View full text Add to dashboard Cite

High-Risk Lineages of Hybrid Plasmids Carrying Virulence and Carbapenemase Genes

Shapovalova,

Chulkova,

Ageevets

et al. 2024

Antibiotics

View full text Add to dashboard Cite

Background/Objectives: Carbapenem-resistant Enterobacterales (CRE) are a global health threat due to their high morbidity and mortality rates and limited treatment options. This study examines the plasmid-mediated transmission of virulence and antibiotic resistance determinants in carbapenem-resistant Klebsiella pneumoniae (Kpn) and Escherichia coli (E. coli) isolated from Russian hospitals. Methods: We performed short- and long-read whole-genome sequencing of 53 clinical isolates (48 Kpn and 5 E. coli) attributed to 15 genetic lineages and collected from 21 hospitals across nine Russian cities between 2016 and 2022. Results: The plasmid analysis identified 18 clusters that showed high concordance with replicon typing, with all clusters having a major replicon type. The majority of plasmids in the IncHI1B(pNDM-MAR)/IncFIB(pNDM-Mar)-like cluster (79.16%) carried both antibiotic resistance genes (e.g., blaNDM-1 and blaOXA-48) and virulence factors (VFs) such as siderophore genes. We hypothesized that hybrid plasmids could play a critical role in the dissemination of antibiotic resistance genes and VFs. Comparative analyses with global plasmid databases revealed high-risk lineages of hybrid plasmids that are predominantly spread throughout Russia at present. Conclusions: Our findings underscore the importance of monitoring plasmid backbones for clinical management, surveillance, and infection control activities.

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Deciphering the relative importance of genetic elements in hypervirulent Klebsiella pneumoniae to guide countermeasure development

Cited by 3 publications

References 29 publications

What defines hypervirulent Klebsiella pneumoniae?

What defines hypervirulent Klebsiella pneumoniae?

A Step Forward in Hypervirulent Klebsiella pneumoniae Diagnostics

High-Risk Lineages of Hybrid Plasmids Carrying Virulence and Carbapenemase Genes

Contact Info

Product

Resources

About