Deciphering the role of alkyl chain length on interaction study of antidepressant drug-cationic surfactants in imidazolium based ionic liquid

Study of the molecular interaction of a phosphonium-based ionic liquid within myo-inositol and non-steroidal anti-inflammatory drugs

“…A stalagmometer (ABGIL Borosilicate, India) was used to determine the surface tension of [P666 (14)][TMPP] and study the effect of myo-inositol (mM)/ NSAIDs. The stalagmometer was calibrated using doubledistilled water.…”

“…The stalagmometer was calibrated using doubledistilled water. The "drop counts method" was used to calculate the surface tension and CMC of [P666 (14)][TMPP]/MI-NSAIDs at a temperature of 299 ± 0.5 K.…”

“…A study of the CMC value of the PIL, i.e. [P666 (14)][TMPP], in the presence of myo-inositol (mM)/ NSAIDs, i.e., ASP or IBU, was performed using digital conductivity (ESICO International, India model Alpha-06). An aqueous solution of potassium chloride (0.1 M and 0.01 M) was used to calibrate the cell constant before each measurement.…”

“…An aqueous solution of potassium chloride (0.1 M and 0.01 M) was used to calibrate the cell constant before each measurement. A micropipette was used to gradually add [P666 (14)][TMPP] solution and the conductance was measured at a temperature of 299 ± 0.5 K.…”

“…11,12 They are clean and efficient and are potential alternatives to volatile organic solvents (VOSs). 13 Phosphonium-based ionic liquids (PILs) represent the 3 rd generation of ILs, and their versatility makes them indispensable, 14 including good conductivity, 15 high thermal stability, 16 chemical stability, 17 high surface activity, 18 and non-ammability, 19 among other properties. PILs have rapidly established themselves in a wide range of applications, especially as additives in cosmetics, agrochemicals, drug delivery, and bio-extraction.…”