Over 100 small-to moderate-sized earthquakes, including an Mw 5.0 event, were detected during September 2015 to November 2016 near the town of Cushing, Oklahoma. The seismic sequence was spatial-temporally linked to four wastewater disposal wells within 4 km. We calculate pore pressure and stress perturbations caused by fluid injection at multiple wells and analyze seismic risk in a Coulomb failure stress framework. Despite being more than an order of magnitude smaller than the pore pressure perturbation, the sign of shear stress change, in the sense of assumed right-lateral fault motion, dictates where earthquakes are induced. Most of the relocated earthquakes are located within areas of positive shear stress changes. Our results suggest that poroelastic stress changes also play an essential role in the wastewater disposal environment, and a strategic design of well locations with respect to fault orientation and direction of motion can help mitigate induced seismic hazard. Plain Language Summary Fluid injected into the subsurface is known to induce earthquakes. This study analyzes the relationship between the 2015/2016 Cushing earthquake sequence and wastewater disposal at four wells within 4 km of the sequence. Our results reveal that while pore pressure increase due to fluid diffusion makes the dominant contribution to promote fault slip toward instability, shear stress change in the sense of motion on a preexisting fault is a critical factor that determines where earthquakes can occur. This study suggests that a strategic design of disposal wells locations, with respect to mapped faults, may be an effective way to mitigate injection-induced seismicity.