Decision-making heterogeneity in obsessive-compulsive disorder: ventromedial prefrontal cortex function predicts different treatment outcomes

Cavedini, Paolo; Riboldi, Giovanna; D'Annucci, A.; Belotti, Patrizia; Cisima, Michele; Bellodi, Laura

doi:10.1016/s0028-3932(01)00077-x

Cited by 248 publications

(201 citation statements)

References 22 publications

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“…Bechara et al (2000) state that performance on the gambling task is not related to education, but little data exist regarding the influence of education on IGT performance. Data generally do not support a relationship between education and IGT performance (Cavedini et al, 2002;Lawrence et al, 2006), although one study found that higher education predicted poorer performance (Evans, Kemish, Turnbull, 2004). Education did not predict IGT performance in our sample.…”

Section: Discussioncontrasting

confidence: 92%

Predictors of decision-making on the Iowa Gambling Task: Independent effects of lifetime history of substance use disorders and performance on the Trail Making Test

Barry

Petry

2008

Brain and Cognition

111

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Poor decision-making and executive function deficits are frequently observed in individuals with substance use disorders (SUDs), and executive deficits may contribute to poor decision-making in this population. This study examined the influence of lifetime history of an alcohol, cocaine, heroin, or polysubstance use disorder on decision-making as measured by the Iowa Gambling Task (IGT) after controlling for executive ability, demographic characteristics, and current substance use. Participants (131 with lifetime history of SUD and 37 controls) completed the IGT and two neuropsychological tests: the Trail Making Test and the Controlled Oral Word Association Test. Control participants performed significantly better than those with a lifetime SUD history on the IGT, but performance on the neuropsychological tests was comparable for the two groups. A lifetime SUD diagnosis was associated with performance on the IGT after controlling for covariates, and Trail Making Test performance was associated with IGT performance in both SUD and control participants.

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Section: Discussioncontrasting

confidence: 92%

Predictors of decision-making on the Iowa Gambling Task: Independent effects of lifetime history of substance use disorders and performance on the Trail Making Test

Barry

Petry

2008

Brain and Cognition

111

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“…Subjects with antisocial personality disorder were impaired at inhibiting responses to previously rewarded stimuli in a task similar to the Iowa Gambling Task (42). Subjects with obsessive-compulsive disorder also showed deficits on tasks related to the integrity of the OMPCC (43) including the Iowa Gambling Task (44). Thus, other psychiatric conditions, with similar or related behaviors could also involve an underlying deficit in the OMPCC.…”

Section: Discussionmentioning

confidence: 99%

Evidence for a dysfunctional prefrontal circuit in patients with an impulsive aggressive disorder

Best

Williams

Coccaro

2002

Proc. Natl. Acad. Sci. U.S.A.

276

155

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Humans with lesions to the orbital͞medial prefrontal cortex and interconnected areas display impulsive aggressive behavior. To examine further the relationship between impulsive aggression and orbital͞medial prefrontal dysfunction, we measured the behavioral performance of psychiatric patients with a disorder characterized by impulsive aggression, Intermittent Explosive Disorder (IED). Presently, no evidence exists for a localized brain lesion in IED subjects. However, on the basis of the location of brain lesions that produce acquired impulsive aggression, we hypothesized that IED subjects would exhibit test performance similar to patients with lesions to the orbital͞medial prefrontal cortex. Subjects with IED and controls were administered three tests sensitive to lesions of the orbital͞medial prefrontal circuit: the Iowa Gambling Task, facial emotion recognition, and odor identification, and two control tests of working memory. On the gambling task, IED subjects continued to make disadvantageous decisions throughout the 100 trials, whereas controls learned to avoid disadvantageous decisions. On the facial recognition test, IED subjects were impaired at recognizing ''anger,'' ''disgust,'' and ''surprise,'' and they were biased to label neutral faces with ''disgust'' and ''fear.'' On odor identification, IED subjects were mildly anosmic and were impaired relative to controls. However, on the working memory control tests, both groups performed similarly. Across tests, the performance of IED subjects resembles the performance of patients with orbital͞medial prefrontal lesions in previous studies. These results extend the link between dysfunction of the orbital͞medial prefrontal circuit and impulsive aggressive behavior.

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“…Behaviorally, patients with OCD show evidence of impaired reward learning [511] and impaired performance on gambling tasks that predict pharmacologic treatment response [512,513]. Despite the overlap of OCD and substance-use disorders in terms of phenotype, neurobiology, comorbidities, and neurochemistry [514], few empirical studies have directly assessed reward-system integrity in OCD.…”

Section: Reviewmentioning

confidence: 99%

Reward circuitry dysfunction in psychiatric and neurodevelopmental disorders and genetic syndromes: animal models and clinical findings

Dichter

Damiano

Allen

2012

J Neurodevelop Disord

254

207

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This review summarizes evidence of dysregulated reward circuitry function in a range of neurodevelopmental and psychiatric disorders and genetic syndromes. First, the contribution of identifying a core mechanistic process across disparate disorders to disease classification is discussed, followed by a review of the neurobiology of reward circuitry. We next consider preclinical animal models and clinical evidence of reward-pathway dysfunction in a range of disorders, including psychiatric disorders (i.e., substance-use disorders, affective disorders, eating disorders, and obsessive compulsive disorders), neurodevelopmental disorders (i.e., schizophrenia, attention-deficit/hyperactivity disorder, autism spectrum disorders, Tourette’s syndrome, conduct disorder/oppositional defiant disorder), and genetic syndromes (i.e., Fragile X syndrome, Prader–Willi syndrome, Williams syndrome, Angelman syndrome, and Rett syndrome). We also provide brief overviews of effective psychopharmacologic agents that have an effect on the dopamine system in these disorders. This review concludes with methodological considerations for future research designed to more clearly probe reward-circuitry dysfunction, with the ultimate goal of improved intervention strategies.

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Decision-making heterogeneity in obsessive-compulsive disorder: ventromedial prefrontal cortex function predicts different treatment outcomes

Cited by 248 publications

References 22 publications

Predictors of decision-making on the Iowa Gambling Task: Independent effects of lifetime history of substance use disorders and performance on the Trail Making Test

Predictors of decision-making on the Iowa Gambling Task: Independent effects of lifetime history of substance use disorders and performance on the Trail Making Test

Evidence for a dysfunctional prefrontal circuit in patients with an impulsive aggressive disorder

Reward circuitry dysfunction in psychiatric and neurodevelopmental disorders and genetic syndromes: animal models and clinical findings

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