Decision-making impairment in schizophrenia: Relationships with positive symptomatology

Struglia, F.; Stratta, Paolo; Gianfelice, Daniela; Pacifico, R.; Riccardi, Ilaria; Rossi, Alessandro

doi:10.1016/j.neulet.2011.07.017

Cited by 28 publications

(23 citation statements)

References 35 publications

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“…The prevalence of schizophrenia, which is associated with poor performance in the IGT (Kim et al 2007; Kim et al 2009; Shurman et al 2005; Struglia et al 2011) and increased impulsivity (Ahn et al 2011), is greater in males than females (Abel et al 2010). Greater risk-taking and impulsivity are characteristic symptoms of attention deficit hyperactivity disorder (Evenden 1999), which is diagnosed ten times more frequently in males than females (McCarthy et al 2012).…”

Section: Discussionmentioning

confidence: 99%

Sex differences in animal models of decision making

Orsini

Setlow

2016

J of Neuroscience Research

106

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The ability to weigh the costs and benefits of various options in order to make an adaptive decision is critical to an organism’s survival and well-being. Many psychiatric diseases are characterized by maladaptive decision-making, indicating the need to better understand the mechanisms underlying this process and the ways in which it is altered in pathological conditions. Great strides have been made in uncovering these mechanisms, but the majority of what is known comes from studies conducted solely in male subjects. In recent years, decision-making research has begun to include females to determine whether sex differences exist and to identify the mechanisms that contribute to such differences. This review will begin by describing studies that have examined sex differences in animal (largely rodent) models of decision-making. Possible explanations, both theoretical and biological, for such differences in decision- making will then be considered. The review will conclude with a discussion of the implications of sex differences in decision-making for understanding psychiatric conditions.

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Section: Discussionmentioning

confidence: 99%

Sex differences in animal models of decision making

Orsini

Setlow

2016

J of Neuroscience Research

106

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“…It is plausible that lateral orbitofrontal structural aberrations contribute to impaired decision making, affecting one's overall functioning. There is a wealth of evidence examining decision making in adults with an established diagnosis of schizophrenia and bipolar disorder [67][68][69][70][71][72] ; however, the nature and extent of the relationship between brain maturation and the development of decision-making in youth, and across the broader psychosis spectrum, has yet to be explored. We also found that increased SA in the postcentral gyrus was associated with less severe negative symptoms and better executive cognition.…”

Section: Brain-behavior Relationshipsmentioning

confidence: 99%

Structural brain alterations in youth with psychosis and bipolar spectrum symptoms

Jalbrzikowski

Freedman

Hegarty

et al. 2018

Preprint

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Objective: Adults with established diagnoses of serious mental illness (bipolar disorder and schizophrenia) exhibit structural brain abnormalities, yet less is known about how such abnormalities manifest earlier in development. Methods:We analyzed the data publicly available from the Philadelphia Neurodevelopmental Cohort (PNC).Structural magnetic resonance neuroimaging data (sMRI) were collected on a subset of the PNC (N=989, ages 9-22 years old). We calculated measures of cortical thickness (CT) and surface area (SA), along with subcortical volumes. Study participants were assessed for psychiatric symptomatology via structured interview and the following groups were created: typically developing (TD, N=376), psychosis spectrum (PS, N=113), bipolar spectrum (BP, N=117), and BP + PS (N=109). We examined group and developmental differences in sMRI measures. We also examined to what extent any structural aberration was related to neurocognition, global functioning, and clinical symptomatology. Results:In comparison to all other groups, PS youth exhibited significantly reduced SA in orbitofrontal, cingulate, precentral, and postcentral regions. PS youth also exhibited reduced thalamic volume in comparison to all other groups. Strongest effects for precentral and posterior cingulate SA reductions were seen during early adolescence (ages 13-15) in PS youth. Strongest effects for reductions in thalamic volume and orbitofrontal and postcentral SA were observed in mid-adolescence (16-18 years) in PS youth. Across groups, better overall functioning was associated with increased lateral orbitofrontal SA. Increased postcentral SA was associated with better executive cognition and less severe negative symptoms in the entire sample. Conclusion:In a community-based sample, we found that reduced cortical SA and thalamic volume are present early in adolescent development in youth with psychosis spectrum symptoms, but not in youth with bipolar spectrum symptoms, or with both bipolar and psychosis spectrum symptoms. These findings point to potential biological distinctions between psychosis and bipolar spectrum conditions, which may suggest additional biomarkers relevant to early identification.

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“…Decision-making deficits are commonly observed in a number of psychiatric conditions including attention-deficit hyperactivity disorder (ADHD; [2]), substance abuse [3], Parkinson’s Disease [4,5,6], problem gambling [7,8] and schizophrenia [9, 10, 11,12]. These decision-making deficits can have devastating consequences and may contribute to the poor outcomes for afflicted individuals.…”

Section: 0 Introductionmentioning

confidence: 99%

Medial prefrontal cortex lesions impair decision-making on a rodent gambling task: Reversal by D1 receptor antagonist administration

Paine

Asinof

Diehl

et al. 2013

Behavioural Brain Research

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Decision-making is a complex cognitive process that is impaired in a number of psychiatric disorders. In the laboratory, decision-making is frequently assessed using “gambling” tasks that are designed to simulate real-life decisions in terms of uncertainty, reward and punishment. Here, we investigate whether lesions of the medial prefrontal cortex (PFC) cause impairments in decision-making using a rodent gambling task (rGT). In this task, rats have to decide between 1 of 4 possible options: 2 options are considered “advantageous” and lead to greater net rewards (food pellets) than the other 2 “disadvantageous” options. Once rats attained stable levels of performance on the rGT they underwent sham or excitoxic lesions and were allowed to recover for 1 week. Following recovery, rats were retrained for 5 days and then the effects of a dopamine D1-like receptor antagonist (SCH23390) or a D2-like receptor antagonist (haloperidol) on performance were assessed. Lesioned rats exhibited impaired decision-making: they made fewer advantageous choices and chose the most optimal choice less frequently than did sham-operated rats. Administration of SCH23390 (0.03 mg/kg), but not haloperidol (0.015–0.03 mg/kg) attenuated the lesion-induced decision-making deficit. These results indicate that the medial PFC is important for decision-making and that excessive signaling at D1 receptors may contribute to decision-making impairments.

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Decision-making impairment in schizophrenia: Relationships with positive symptomatology

Cited by 28 publications

References 35 publications

Sex differences in animal models of decision making

Sex differences in animal models of decision making

Structural brain alterations in youth with psychosis and bipolar spectrum symptoms

Medial prefrontal cortex lesions impair decision-making on a rodent gambling task: Reversal by D1 receptor antagonist administration

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