Decision‐making Impairments in Women with Binge Eating Disorder in Comparison with Obese and Normal Weight Women

Danner, Unna N.; Ouwehand, Carolijn; Haastert, Noor L van; Hornsveld, Hellen; Ridder, Denise T. D. de

doi:10.1002/erv.1098

Cited by 108 publications

(97 citation statements)

References 44 publications

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“…These results are consistent with several behavioral studies showing that poor decision-making scores measured by the IGT are found in obese, patients with binge eating disorders, and overweight adolescents (Pignatti et al, 2006; Brogan et al, 2010; Verdejo-Garcia et al, 2010; Danner et al, 2012; Fagundo et al, 2012). They are also consistent with previous reports that performance on the IGT was related to the magnitude of weight loss in a diet-induced weight loss intervention in overweight women (Witbracht et al, 2012).…”

Section: Discussionsupporting

confidence: 90%

“…The question is: why do some individuals become insensitive to the future consequences of their unhealthy eating habits and have difficulty making better healthful choices? While some research has found that poorer decision-making capacity may be associated with abnormal eating behaviors, most of these studies have focused on patients with differing forms of eating pathology (Pignatti et al, 2006; Brogan et al, 2010; Danner et al, 2012; Fagundo et al, 2012). In the current study, we evaluate normal individuals who are not medically diagnosed with an eating disorder.…”

Section: Introductionmentioning

confidence: 99%

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Altered dynamics between neural systems sub-serving decisions for unhealthy food

Lin

Xue

et al. 2014

Front. Neurosci.

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Using BOLD functional magnetic resonance imaging (fMRI) techniques, we examined the relationships between activities in the neural systems elicited by the decision stage of the Iowa Gambling Task (IGT), and food choices of either vegetables or snacks high in fat and sugar. Twenty-three healthy normal weight adolescents and young adults, ranging in age from 14 to 21, were studied. Neural systems implicated in decision-making and inhibitory control were engaged by having participants perform the IGT during fMRI scanning. The Youth/Adolescent Questionnaire, a food frequency questionnaire, was used to obtain daily food choices. Higher consumption of vegetables correlated with higher activity in prefrontal cortical regions, namely the left superior frontal gyrus (SFG), and lower activity in sub-cortical regions, namely the right insular cortex. In contrast, higher consumption of fatty and sugary snacks correlated with lower activity in the prefrontal regions, combined with higher activity in the sub-cortical, insular cortex. These results provide preliminary support for our hypotheses that unhealthy food choices in real life are reflected by neuronal changes in key neural systems involved in habits, decision-making and self-control processes. These findings have implications for the creation of decision-making based intervention strategies that promote healthier eating.

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Section: Discussionsupporting

confidence: 90%

Section: Introductionmentioning

confidence: 99%

Altered dynamics between neural systems sub-serving decisions for unhealthy food

Lin

Xue

et al. 2014

Front. Neurosci.

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“…To put it differently, patients suffering from BED make disadvantageous decisions and fail to adapt their behavior in the face of negative consequences. The first few behavioral studies are in accordance with the idea of decision-making impairments in BED (Danner et al, 2012;Davis et al, 2010;Svaldi et al, 2010;Voon et al, 2015).…”

Section: Introductionsupporting

confidence: 64%

Impaired Flexible Reward-Based Decision-Making in Binge Eating Disorder: Evidence from Computational Modeling and Functional Neuroimaging

Reiter

Heinze

Schlagenhauf

et al. 2016

Neuropsychopharmacol

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Despite its clinical relevance and the recent recognition as a diagnostic category in the DSM-5, binge eating disorder (BED) has rarely been investigated from a cognitive neuroscientific perspective targeting a more precise neurocognitive profiling of the disorder. BED patients suffer from a lack of behavioral control during recurrent binge eating episodes and thus fail to adapt their behavior in the face of negative consequences, eg, high risk for obesity. To examine impairments in flexible reward-based decision-making, we exposed BED patients (n = 22) and matched healthy individuals (n = 22) to a reward-guided decision-making task during functional resonance imaging (fMRI). Performing fMRI analysis informed via computational modeling of choice behavior, we were able to identify specific signatures of altered decision-making in BED. On the behavioral level, we observed impaired behavioral adaptation in BED, which was due to enhanced switching behavior, a putative deficit in striking a balance between exploration and exploitation appropriately. This was accompanied by diminished activation related to exploratory decisions in the anterior insula/ventro-lateral prefrontal cortex. Moreover, although so-called model-free reward prediction errors remained intact, representation of ventro-medial prefrontal learning signatures, incorporating inference on unchosen options, was reduced in BED, which was associated with successful decision-making in the task. On the basis of a computational psychiatry account, the presented findings contribute to defining a neurocognitive phenotype of BED.

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“…People with substance abuse disorders exhibited impaired IGT performance in the absence of impaired delaydependent memory or executive functioning (Gonzalez et al, 2007;Quednow et al, 2007). Impaired decision-making on the IGT has also been observed in people with binge eating disorder and sufferers of alcoholism (Danner et al, 2012;Le Berre et al, 2014). Similarly, patients with schizophrenia also exhibit deficient IGT performance (Kim et al, 2009;Wasserman et al, 2012;Brambilla et al, 2013;Fond et al, 2013), although this finding has not been consistently observed (Turnbull et al, 2006).…”

Section: Impaired Decision-making Across Neuropsychiatric Populationsmentioning

confidence: 91%

Neural mechanisms regulating different forms of risk-related decision-making: Insights from animal models

Orsini

Moorman

Young

et al. 2015

Neuroscience & Biobehavioral Reviews

133

110

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Over the past 20 years there has been a growing interest in the neural underpinnings of cost/benefit decision-making. Recent studies with animal models have made considerable advances in our understanding of how different prefrontal, striatal, limbic and monoaminergic circuits interact to promote efficient risk/reward decision-making, and how dysfunction in these circuits underlies aberrant decision-making observed in numerous psychiatric disorders. This review will highlight recent findings from studies exploring these questions using a variety of behavioral assays, as well as molecular, pharmacological, neurophysiological, and translational approaches. We begin with a discussion of how neural systems related to decision subcomponents may interact to generate more complex decisions involving risk and uncertainty. This is followed by an overview of interactions between prefrontal-amygdala-dopamine and habenular circuits in regulating choice between certain and uncertain rewards and how different modes of dopamine transmission may contribute to these processes. These data will be compared with results from other studies investigating the contribution of some of these systems to guiding decision-making related to rewards vs. punishment. Lastly, we provide a brief summary of impairments in risk-related decision-making associated with psychiatric disorders, highlighting recent translational studies in laboratory animals.

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Decision‐making Impairments in Women with Binge Eating Disorder in Comparison with Obese and Normal Weight Women

Abstract: This study demonstrates that patients with BED display decision-making deficits on the IGT comparable with other forms of disordered eating. Future research should focus on unravelling the processes underlying the deficits.

Cited by 108 publications

References 44 publications

Altered dynamics between neural systems sub-serving decisions for unhealthy food

Altered dynamics between neural systems sub-serving decisions for unhealthy food

Impaired Flexible Reward-Based Decision-Making in Binge Eating Disorder: Evidence from Computational Modeling and Functional Neuroimaging

Neural mechanisms regulating different forms of risk-related decision-making: Insights from animal models

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