Natural driven ventilation is a widely used technique in hot and arid climate, but it is rarely known that it can lead to significant energy saving in a moderate climate too. In this paper, an existing building is presented that was designed with a passive air conduction system (PACS), where wind and buoyancy effects induce air to be exchanged without external energy needs. The aim is to show that the design methodology, using numerical simulation to give accurate results, is able to use them in further developments. Due to this design process, the specific building possesses numerous special properties, including airflow accelerating elements, solar-heated “chimneys”, and the indoor heat sources coming from the industrial technology. As the building has been constructed and was equipped with around 750 sensors (integrated and manual), it is possible to analyze the ongoing physical phenomenon in a highly detailed way and to collect the experienced dataset for further investigations. The current study carries out a complex validation of the design and the used numerical methods to give general design rules for further PACS design and support following investigations, e.g., occupant comfort prediction or latent heat storage calculation. The experiences showed that the developed computational fluid dynamics technique gives a below 99% accuracy in the velocity and the temperature field, and approximately 85% accuracy in the volume flow values, resulting in a good prediction for aerodynamic characterization of buildings, i.e., passive ventilation air exchange rate.