In-Person, Hybrid, and Virtual Cardiac Rehabilitation 1 C ardiac rehabilitation (CR) reduces hospitalizations and mortality and improves functional status and quality of life for patients with cardiovascular disease. [1][2][3][4][5][6][7][8][9][10] Despite its benefits, only 24% of eligible patients participate in CR. [11][12][13] Indeed, on a global level, CR is only offered in roughly 50% of countries. 14 Root causes of low participation include patient financial and logistic barriers, bias in referrals, and limited program capacity, among others. [15][16][17][18][19] Up to 14% of adults live in an area without a CR center, and even if all CR centers operated at 110% capacity, only 40% of eligible patients could be served. 20 Cardiac rehabilitation holds tremendous promise but is underutilized and, often, unavailable.In an effort to make CR more accessible, the delivery of CR has evolved to include both traditional in-person sessions and newer virtual sessions. [21][22][23][24][25][26][27] Programs may offer virtual sessions only or a hybrid of in-person and virtual sessions. 28 Evidence continues to build that virtual and hybrid CR offer similar safety and efficacy compared with in-person CR. 9,[29][30][31][32][33][34][35][36] The COVID-19 pandemic has accelerated the adoption of virtual and hybrid CR in response to limited or suspended in-person services. 37 Nonetheless, there have been few studies that compare outcomes among in-person, hybrid, and virtual CR in clinical practice, representing a real-world setting. At the University of California, San Francisco (UCSF), the COVID-19 public health emergency necessitated the creation of a CR program that gave patients the choice to limit in-person CR visits and receive much, or all, of their CR virtually. This presented a unique opportunity to compare clinical outcomes between in-person, hybrid, and virtual CR at a single academic center.Our primary objective was to compare, in UCSF CR patients, the association of in-person, hybrid, and virtual CR with change in functional capacity between enrollment and completion, measured by distance completed on the 6-min walk test (6MWT). We hypothesized that change in the 6MWT would be similar between the in-person, hybrid, and virtual CR cohorts. In addition, we compared attainment of blood pressure (BP) control, change in waistto-hip ratio, depressive symptoms, anxiety symptoms, and cardiac self-efficacy. We also described completion rates, adverse events, and patient and staff qualitative perceptions of CR.
METHODSThis cohort study included all patients who enrolled in CR at the UCSF between October 22, 2019, and May 10, 2021. All subjects were ≥18 yr men and women, and all races, ethnicities, and spoken languages were included. There were no specific inclusion or exclusion criteria related to education, literacy, or technology use. The study was reviewed and approved by the UCSF Institutional Review Board . Quantitative data were collected from electronic health records collected for patient care purposes, and written ...