Declarative and procedural memory in bipolar disorder

Gorp, Wilfred G. van; Altshuler, Lori L.; Theberge, David C.; Mintz, Jim

doi:10.1016/s0006-3223(98)00336-9

Cited by 138 publications

(116 citation statements)

References 25 publications

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“…Cognitive impairments have previously been described in FH and also in manic, depressed, and euthymic BD patients (Sobczak et al, 2002c;Rossi et al, 2000;Martinez-Aran et al, 2000;Ferrier et al, 1999;Murphy et al, 1999;Rubinsztein et al, 2000). The cognitive deficits in BD may be partially explained by abnormalities in functional brain structures and/or metabolism (Stoll et al, 2000;Manji et al, 2000;van Gorp et al, 1999;Coffman et al, 1990). As cognitive impairments are present in FH and persist during clinical remission in BD patients, they may be regarded as trait markers (Henry et al, 1973;van Gorp et al, 1998;Murphy et al, 1999;Coffman et al, 1990;Ferrier et al, 1999;Rubinsztein et al, 2000).…”

Section: Discussionmentioning

confidence: 98%

Pronounced Cognitive Deficits Following an Intravenous L-Tryptophan Challenge in First-Degree Relatives of Bipolar Patients Compared to Healthy Controls

Sobczak

Honig

Schmitt

et al. 2002

Neuropsychopharmacol

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Cognitive impairment has repeatedly been described in bipolar disorders (BD). Serotonin (5-hydroxytryptophan; 5-HT) is possibly involved in these cognitive processes, more particularly in executive functions, learning, memory, and attention. The aim of this study was to investigate serotonergic vulnerability and its relation to cognitive functioning in healthy first-degree relatives of BD patients. We investigated the effects of an intravenous (i.v.) tryptophan (Trp) challenge and placebo on cognitive performance in 30 healthy firstdegree relatives of bipolar patients (FH) and 15 matched controls in a double-blind crossover design. A distinction was made between relatives of type I BD patients (FH I) and type II BD patients (FH II). Performances on planning, memory, attention, and psychomotor tasks were assessed 3 h after Trp infusion. After Trp, planning and attention were impaired in FH subjects but not in controls. Independent of Trp, FH subjects showed cognitive deficits on memory, focused and divided attention, and psychomotor performance. FH I subjects showed more pronounced cognitive impairments then FH II and controls. In all groups, Trp impaired memory and psychomotor performance significantly. In conclusions, cognitive deficits in FH following Trp may reflect a central 5-HT vulnerability in frontal brain areas. Independent of Trp, cognitive deficits in FH provide evidence for a trait marker for BD.

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Section: Discussionmentioning

confidence: 98%

Pronounced Cognitive Deficits Following an Intravenous L-Tryptophan Challenge in First-Degree Relatives of Bipolar Patients Compared to Healthy Controls

Sobczak

Honig

Schmitt

et al. 2002

Neuropsychopharmacol

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show abstract

“…Impairments have been reported during the depressed, manic, and euthymic phases of illness in tests of verbal memory, such as story recitation [6] and word list recall [12][13]15,18]. One study comparing depressed and euthymic patients versus healthy controls found an additional impairment for nonverbal memory, but only in acutely depressed patients, whereas the nonverbal memory performance for euthymic patients was comparable to that of controls [19].…”

Section: Memorymentioning

confidence: 99%

Cognitive and neurological impairment in mood disorders

Marvel

Paradiso

2004

Psychiatric Clinics of North America

210

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“…Even when stable, BD patients have been shown to demonstrate mild, selective impairments of verbal learning and memory and sustained attention (Dickerson et al 2001;Gourovitch et al 1999;Martinez-Aran et al 2004;Rubinsztein et al 2000;Seidman et al 2002;van Gorp et al 1999;Zubieta et al 2001). In a few studies, stable BD patients have shown impairments of psychomotor speed, card sorting, verbal fluency, and visual memory (Quraishi and Frangou 2002), but they rarely show impaired general intelligence, motor function, praxis, selective attention, or language.…”

Section: Introductionmentioning

confidence: 99%