Decline in circulating neuropeptide Y levels in normal elderly human subjects

Chiodera, P.; Volpi, R.; Pilla, S.; Cataldo, Simona; Coiro, V.

doi:10.1530/eje.0.1430715

Cited by 15 publications

(7 citation statements)

References 4 publications

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“…It should be noted that in the present study NPY was measured peripherally which does not necessarily reflect its central expression. Nevertheless, consistent with our results a prior study investigating male subjects also demonstrated a decline of plasma NPY levels with increasing age as well as no correlation with BMI (Chiodera et al, 2000). Lastly, our observations match previous findings that found lower plasma PP in adults compared to children (Hanukoglu et al, 1990).…”

Section: Discussionsupporting

confidence: 93%

Pancreatic Polypeptide but Not Other Members of the Neuropeptide Y Family Shows a Moderate Association With Perceived Anxiety in Obese Men

Schaper

Hofmann

Wölk

et al. 2020

Front. Hum. Neurosci.

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Section: Discussionsupporting

confidence: 93%

Pancreatic Polypeptide but Not Other Members of the Neuropeptide Y Family Shows a Moderate Association With Perceived Anxiety in Obese Men

Schaper

Hofmann

Wölk

et al. 2020

Front. Hum. Neurosci.

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“…Another important finding from the postmortem study is the age-related decline in NPY levels in the prefrontal cortex. A decline in plasma NPY levels was reported in normal elderly human subjects (Chiodera et al, 2000). Several studies in rodents supports a decline in brain NPY levels with advanced age (Vela et al, 2003;Hattiangady et al, 2005;Higuchi et al, 1988).…”

Section: Discussionmentioning

confidence: 88%

Human NPY promoter variation rs16147:T>C as a moderator of prefrontal NPY gene expression and negative affect

et al. 2010

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Studies in humans and animals suggest a role for NPY in the mediation of behavioral stress responses. Here, we examined whether the NPY promoter variant rs16147:T>C is functional for expression of NPY in a brain region relevant for behavioral control, anxiety and depression, the anterior cingulate cortex. In silico analysis of DNA structural profile changes produced by rs16147 variation suggests allelic differences in protein binding at the rs16147 site. This was confirmed by electrophoretic mobility shift assay, demonstrating that the rs16147 C-allele has strongly reduced affinity for a yet unknown factor compared to the T-allele. Analyzing 107 human post-mortem brain samples we show that allelic variation at rs16147 contributes to regulation of NPY mRNA and peptide levels in this region. Specifically, the C-allele leads to increased gene expression. In agreement with the molecular findings, rs16147:T>C is associated with anxiety and depressive symptoms in 314 young adults via a gene x environment interaction with early childhood adversity, replicating the recent finding of rs16147-C as a risk factor for stress related psychopathology. Our results show the importance of rs16147:T>C for regulation of NPY gene expression and brain function.

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“…In humans, NPY levels in the cerebrospinal fluid may be increasing with aging in women, but not in men (Taniguchi et al 1994). However, other researchers observed a decline in plasma NPY levels in humans that significantly correlated with increasing age (Chiodera et al 2000). In general, as compared to certain animal species, NPY seems to play less important role in the development of the anorexia of aging in humans.…”

Section: Neuropeptide Ymentioning

confidence: 82%

Mechanisms of the anorexia of aging—a review

Wysokiński

Sobów

Kłoszewska

et al. 2015

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189

148

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Many, even healthy, older people fail to adequately regulate food intake and experience loss of weight. Aging-associated changes in the regulation of appetite and the lack of hunger have been termed as the anorexia of aging. The etiology of the anorexia of aging is multi-factorial and includes a combination of physiological changes associated with aging (decline in smell and taste, reduced central and peripheral drive to eat, delayed gastric emptying), pathological conditions (depression, dementia, somatic diseases, medications and iatrogenic interventions, oral-health status), and social factors (poverty, loneliness). However, exact mechanisms of the anorexia of aging remain to be elucidated. Many neurobiological mechanisms may be secondary to age-related changes in body composition and not associated with anorexia per se. Therefore, further studies on pathophysiological mechanisms of the anorexia of aging should employ accurate measurement of body fat and lean mass. The anorexia of aging is associated with protein-energy malnutrition, sarcopenia, frailty, functional deterioration, morbidity, and mortality. Since this symptom can lead to dramatic consequences, early identification and effective interventions are needed. One of the most important goals in the geriatric care is to optimize nutritional status of the elderly.

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Decline in circulating neuropeptide Y levels in normal elderly human subjects

Cited by 15 publications

References 4 publications

Pancreatic Polypeptide but Not Other Members of the Neuropeptide Y Family Shows a Moderate Association With Perceived Anxiety in Obese Men

Pancreatic Polypeptide but Not Other Members of the Neuropeptide Y Family Shows a Moderate Association With Perceived Anxiety in Obese Men

Human NPY promoter variation rs16147:T>C as a moderator of prefrontal NPY gene expression and negative affect

Mechanisms of the anorexia of aging—a review

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