The article explores future directions toward the conservation of the state of Arizona, aiming to preserve its multiple natural resources, including landscapes, wildlife, flora, unique ecosystems, and water resources. We evaluate the current governmental plans and laws focused on conservation, highlighting their impacts and identifying the existing gaps. Then, by analyzing such gaps, we uncover the main open conservation challenges within the state, such as urban expansion, climate change, water resource management, spreading of invasive species, and uranium mining and related activities, discussing their potential impact on future conservation efforts. Finally, the article introduces targeted strategies to enhance conservation outcomes, focusing on the importance of collaborative governance, innovative conservation technologies, multidisciplinary solutions, and law revisions. By adopting a forward-looking and multidisciplinary approach, we outline multiple prospective pathways for ensuring the long-term sustainability of Arizona’s natural resources, contributing to the wide global discussion on environmental conservation.