Decline in somatomedin-C (insulin-like growth factor-1) with experimentally induced zinc deficiency in human subjects

Cossack, Zafrallah T.

doi:10.1016/0261-5614(91)90008-z

Cited by 44 publications

(26 citation statements)

References 29 publications

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“…Dietary protein restriction has been shown to reduce circulating serum IGF-1 concentrations 31 ; diarrheal illness may induce moderate protein deficiency through decreased dietary intake, malabsorption, or catabolic loss. Zinc deficiency is also associated with low IGF-1 concentrations 32 ; diarrhea may induce or exacerbate zinc deficiency through excess fecal losses. 32 Moreover, zinc supplementation in young children has been shown to increase plasma concentrations of IGF-1 while also reducing the risk of diarrhea episodes and increasing linear growth velocity.…”

Section: Discussionmentioning

confidence: 99%

“…Zinc deficiency is also associated with low IGF-1 concentrations 32 ; diarrhea may induce or exacerbate zinc deficiency through excess fecal losses. 32 Moreover, zinc supplementation in young children has been shown to increase plasma concentrations of IGF-1 while also reducing the risk of diarrhea episodes and increasing linear growth velocity. 33 Alternatively, zinc deficiency may cause reduced concentrations of serum IGF-1 while also increasing risk of diarrhea.…”

Section: Discussionmentioning

confidence: 99%

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Acute Illness is Associated with Suppression of the Growth Hormone Axis in Zimbabwean Infants

Jones¹,

Rukobo²,

Chasekwa³

et al. 2015

The American Society of Tropical Medicine and Hygiene

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Abstract. Frequent infections contribute to childhood stunting in developing countries but the causal pathways are uncertain. We tested the hypothesis that intercurrent illnesses suppress the growth hormone axis through reductions in insulin-like growth factor 1 (IGF-1). In a birth cohort of 202 HIV-unexposed Zimbabwean infants, we analyzed data on 7-day illness recall and measured plasma interleukin-6, C-reactive protein, alpha-1-acid glycoprotein, and IGF-1 by enzyme-linked immunosorbent assay, at age 6 weeks, and then 3, 6, 12, and 18 months. Children with recent acute illness had lower IGF-1 concentrations than healthy children and IGF-1 correlated inversely (P 0.05) with inflammatory biomarkers at most time points between 3 and 18 months. Using path analysis, we showed that cough and fever had a predominantly indirect effect on suppressing IGF-1, through the acute-phase response, whereas diarrhea had a predominantly direct effect on IGF-1. Acute illness may therefore impact the growth hormone axis through both direct and indirect pathways.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Acute Illness is Associated with Suppression of the Growth Hormone Axis in Zimbabwean Infants

Jones¹,

Rukobo²,

Chasekwa³

et al. 2015

The American Society of Tropical Medicine and Hygiene

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“…Changes in the GH-IGF axis alone might not explain the growth inhibition observed in zinc deficiency. In humans, poor zinc status has been associated with low circulating IGF-1 concentrations even in presence of adequate caloric intake [101]. In zinc deficient short children, zinc supplementation was effective in inducing growth.…”

Section: Minerals and Igf-1 In The Fire Of Frailtymentioning

confidence: 99%

IGF-1, the Cross Road of the Nutritional, Inflammatory and Hormonal Pathways to Frailty

et al. 2013

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The decline in functional capacity is a heterogeneous phenomenon in the elderly. An accelerated ageing determines a frail status. It results in an increased vulnerability to stressors for decreased physiological reserves. The early identification of a frail status is essential for preventing loss of functional capacity, and its clinical consequences. Frailty and mobility limitation result from an interplay of different pathways including multiple anabolic deficiency, inflammation, oxidative stress, and a poor nutritional status. However, the age-related decline in insulin-like growth factor 1 (IGF-1) bioactivity deserves special attention as it could represent the ideal crossroad of endocrine, inflammatory, and nutritional pathways to frailty. Several minerals, namely magnesium, selenium, and zinc, appear to be important determinants of IGF-1 bioactivity. This review aims to provide an overview of the potential usefulness of nutrients modulating IGF-1 as potential therapeutic targets in the prevention of mobility limitation occurring in frail older subjects.

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“…It is well documented that zinc deficiency in rats causes not only growth retardation but also a decrease in both IGF-I plasma concentrations and GH receptors [20][21][22] . Decline in IGF-I was shown with experimentally induced zinc deficiency in human subjects 23 and transient partial growth hormone deficiency due to zinc deficiency were reported in children 24,25 . When oral zinc replacement was given, they had a significant increase in growth rate which continued for at least 2 years, and subsequent growth hormone tests were normal 25 .…”

Section: Discussionmentioning

confidence: 98%

“Functional Food” for Acceleration of Growth in Short Children Born Small for Gestational Age

Zadik

Sinai

Zung

et al. 2010

Journal of Pediatric Endocrinology and Metabolism

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Objective: To assess the effect of nutritional supplementation on growth in short children born small for gestational age (SGA). Patients: Fifty four short but otherwise healthy children (26 boys), 6.4±1.8 years of age, were referred for growth retardation. Methods: Following a 6 month observation period the participants were randomly allocated to receive growth hormone therapy (GH) 1.26 IU/kg/day (0.042 mg/kg/day) or nutritional program (NUT) or passive observation (OBS). Patients in the nutritional program received 10 mg/day iron, 11 mg zincthree times a week and 10000 IU/week of vitamin A. The following parameters were obtained 3 monthly: height, weight, dietary intake and serum IGF-1. Results: Six months of nutritional supplement induced growth acceleration somewhat lower than that seen in the growth hormone treated children, but significantly greater than noted in the observation group (OBS 4.6±1.3, NUT 7.9±1.7, GH 9.1±1.8 cm/yr, P< 0·001). Conclusions: Six months of vitamin A, iron and zinc supplementation induces growth acceleration in short children born SGA with subnormal nutrients intake similar to growth hormone therapy.

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Decline in somatomedin-C (insulin-like growth factor-1) with experimentally induced zinc deficiency in human subjects

Cited by 44 publications

References 29 publications

Acute Illness is Associated with Suppression of the Growth Hormone Axis in Zimbabwean Infants

Acute Illness is Associated with Suppression of the Growth Hormone Axis in Zimbabwean Infants

IGF-1, the Cross Road of the Nutritional, Inflammatory and Hormonal Pathways to Frailty

“Functional Food” for Acceleration of Growth in Short Children Born Small for Gestational Age

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