Decline in total serum IgE after treatment for tuberculosis

Adams, J. L.; Schölvinck, Elisabeth H.; Gie, R P; Potter, P C; Beyers, Nulda; Ad, Beyers

doi:10.1016/s0140-6736(98)08510-9

Cited by 59 publications

(53 citation statements)

References 31 publications

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“…The latter particularly, in contrast to their diminished lack of skin test reactivity, had high levels of antibodies. The vast majority of these antibodies were found to be of the IgE isotype, generally reported to be interleukin-4-dependent (Yong et al 1989, Adams et al 1999, which could condition the high frequency of anergic states observed in this group.…”

Section: Discussionmentioning

confidence: 86%

“…For anti-PPD IgE a significant difference was observed between patient (TST -) and patient (TST +). (Yong et al 1989, Beyer et al 1998, Adams et al 1999). In addition, it has been reported that IgE concentrations decreased after successful treatment of TB, presumably due to the enhancement of a Th1 response, which suggests that TB up-regulates the Th2 response (Yong et al 1989, Beyer et al 1998.…”

Section: Discussionmentioning

confidence: 99%

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Study of the antibody response against Mycobacterium tuberculosis antigens in Warao Amerindian children in Venezuela

Araujo

Waard

Larrea

et al. 2004

Mem. Inst. Oswaldo Cruz

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Section: Discussionmentioning

confidence: 86%

Section: Discussionmentioning

confidence: 99%

Study of the antibody response against Mycobacterium tuberculosis antigens in Warao Amerindian children in Venezuela

Araujo

Waard

Larrea

et al. 2004

Mem. Inst. Oswaldo Cruz

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“…The strong negative association between delayed hypersensitivity to M. tuberculosis and atopic disease seen in Japanese children [9] and the increase in IgE levels following successful treatment of pulmonary tuberculosis in South Africa [27] suggest that immune responses to mycobacteria are an important means of inhibiting allergic responses. However, it should be appreciated that M. vaccae is unique in its ability to modulate immune responses.…”

Section: Discussionmentioning

confidence: 99%

The effects ofMycobacterium vaccaeon allergen-induced airway responses in atopic asthma

Camporota¹,

Corkhill²,

Long³

et al. 2003

Eur Respir J

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T-helper (Th)2 cytokines play a central role in asthma. Therefore, a double-blind randomised study was conducted to investigate whether heat-killed Mycobacterium vaccae (SRL172), a potent downregulator of Th2 cytokines, can reduce allergen-induced airway responses in patients with atopic asthma.A total 24 male asthmatics participated in this study. A bronchial allergen challenge was performed along with early (EAR) and late asthmatic responses (LAR) 2 weeks before and 3 weeks after a single intradermal injection of SRL172 or placebo. Before and after treatment, serum immunoglobulin (Ig)E levels and in vitro production of interleukin (IL)-5 by peripheral blood lymphocytes were studied.Neither treatment affected the EAR. SRL172 caused a mean 34% reduction of the area under the curve of the forced expiratory volume in one second (FEV1) changes during the LAR, which failed to reach conventional statistical significance when compared with placebo. SRL172 also caused a mean 25% decrease in the maximum fall in FEV1 during LAR, but this was not significantly different from placebo. SRL172 caused a reduction in serum IgE and IL-5 synthesis in vitro 3 weeks post-treatment (p=0.07).This study shows a trend toward significance for the effects of heat-killed Mycobacterium vaccae (SRL172) on allergen-induced airway responses. Further clinical trials, involving multiple dosing, are needed.

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“…In two recent studies, the magnitude of the Th2 response in tuberculosis patients was found to correlate with the extent of disease progression, although it was noted that the relationship between cause and effect remained to be clarified (16,17). The influence of an underlying Th2 response on the outcome of mycobacterial infection may be important in the context of age-related differences in susceptibility to tuberculosis and during coinfection with mycobacteria and intestinal parasites (18).…”

mentioning

confidence: 99%

Contribution of Th1 and Th2 Cells to Protection and Pathology in Experimental Models of Granulomatous Lung Disease

Wangoo

Sparer

Brown³

et al. 2001

The Journal of Immunology

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Mice that had received adoptive transfer of DO11.10 TCR transgenic T cells polarized toward a Th1 or a Th2 phenotype were challenged with Ag-coated beads or with recombinant Mycobacterium tuberculosis expressing the OVA determinant. The resulting bead-induced pulmonary granulomas reflected the phenotype of the adoptively transferred T cells, with the Th2 cells promoting a fibrotic reaction. Mice receiving Th1 cells mounted an epitope-specific protective response to challenge with recombinant M. tuberculosis. Th2 recipients were characterized by enhanced weight loss and lung fibrosis during acute high-dose infection. The combination of TCR transgenic T cells and epitope-tagged mycobacteria provides a novel experimental model for investigation of the pathogenesis of tuberculosis.

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Decline in total serum IgE after treatment for tuberculosis

Cited by 59 publications

References 31 publications

Study of the antibody response against Mycobacterium tuberculosis antigens in Warao Amerindian children in Venezuela

Study of the antibody response against Mycobacterium tuberculosis antigens in Warao Amerindian children in Venezuela

The effects ofMycobacterium vaccaeon allergen-induced airway responses in atopic asthma

Contribution of Th1 and Th2 Cells to Protection and Pathology in Experimental Models of Granulomatous Lung Disease

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