Decline of neural tube defects cases after a folic acid campaign in Nuevo León, México

Villarreal, Laura Martínez de; Pérez, Jesús Zacarías Villarreal; Vázquez, Patricia Arredondo; Herrera, Ricardo H.; Campos, Ma. Del Roble Velazco; López, Roberto Ambriz; Ramírez, José Luis Herrera; Sánchez, Jesús Manuel Yañez; Villarreal, Juan José Morales; Garza, Manuel; Limón, Adriana; López, Arnoldo Téllez; Bárcenas, Mario; García, Juan; Dominguez, Andres; Nuñez, Rogelio Hernández; Ayala, Jorge Luis García; Martínez, Jorge Garza; González, Mario Tijerina; Álvarez, Cristobalina Rodríguez; Castro, Roberto Negrete

doi:10.1002/tera.10094

Cited by 58 publications

(23 citation statements)

References 29 publications

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“…In the first one, carried out in Mexico, women received 5000 μg (5 mg) folic acid for three months, and their red blood cell and plasma folate concentrations significantly increased (Martinez-de Villareal 2001). This strategy was also associated with a 50% decrease in the incidence of anencephaly and spina bifida cases, and a significant reduction in infant mortality and disability after two years (Martinez-de Villareal 2002). In the second study, conducted in New Zealand, a weekly single supplement of 2800 μg (2.8 mg) of folic acid taken for 12 weeks increased women's red blood cell folate to concentrations associated with a reduced risk of bearing a child with a NTD (Norsworthy 2004).…”

Section: Summary Of Main Resultsmentioning

confidence: 99%

Effects and safety of periconceptional folate supplementation for preventing birth defects

Regil

Fernández-Gaxiola

Dowswell

et al. 2009

Cochrane Database of Systematic Reviews

164

182

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Section: Summary Of Main Resultsmentioning

confidence: 99%

Effects and safety of periconceptional folate supplementation for preventing birth defects

Regil

Fernández-Gaxiola

Dowswell

et al. 2009

Cochrane Database of Systematic Reviews

164

182

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“…The 4000-lg/wk dose was included in the design of this study because researchers have shown that high-dose folic acid supplements administered weekly can be effective at preventing NTD (31,32). Although the group who received 4000 lg/wk dose ('571 lg/d) consumed a larger total dose than did the group who received 400 lg/d, the former dose was not as effective at lowering high homocysteine concentrations or increasing plasma or RBC folate concentrations as was the 400-lg/d dose.…”

Section: Discussionmentioning

confidence: 99%

MTHFR 677C→T genotype is associated with folate and homocysteine concentrations in a large, population-based, double-blind trial of folic acid supplementation

Crider

Zhu

Lü

et al. 2011

The American Journal of Clinical Nutrition

128

116

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Background: The methylenetetrahydrofolate reductase (MTHFR) genotype is associated with modification of disease and risk of neural tube defects. Plasma and red blood cell (RBC) folate and plasma homocysteine concentrations change in response to daily intakes of folic acid supplements, but no large-scale or populationbased randomized trials have examined whether the MTHFR genotype modifies the observed response. Objective: We sought to determine whether the MTHFR 677C/T genotype modifies the response to folic acid supplementation during and 3 mo after discontinuation of supplementation. Design: Northern Chinese women of childbearing age were enrolled in a 6-mo supplementation trial of different folic acid doses: 100, 400, and 4000 lg/d and 4000 lg/wk. Plasma and RBC folate and plasma homocysteine concentrations were measured at baseline; after 1, 3, and 6 mo of supplementation; and 3 mo after discontinuation of supplementation. MTHFR genotyping was performed to identify a C/T mutation at position 677 (n = 932). Results: Plasma and RBC folate and homocysteine concentrations were associated with MTHFR genotype throughout the supplementation trial, regardless of folic acid dose. MTHFR TT was associated with lower folate concentrations, and the trend of TT , CC was maintained at even the highest doses. Folic acid doses of 100 lg/d or 4000 lg/wk did not reduce high homocysteine concentrations in those with the MTHFR TT genotype. Conclusion: MTHFR genotype was an independent predictor of plasma and RBC folate and plasma homocysteine concentrations and did not have a significant interaction with folic acid dose during supplementation. This trial was registered at clinicaltrials.gov as NCT00207558.Am J Clin Nutr 2011;93:1365-72.

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“…Mientras que la administración semanal de 5 mg durante tres meses (grupo C) eleva no solo el valor plasmático e intraeritrocitario de folato, sino también el hematocrito en forma significativa lo cuál indica una respuesta de la médula ósea al aporte de la vitamina. La eficacia de esta medida también se evidenció en un estudio previo (13,14) al observar una reducción en la incidencia de DTN (anencefalia 50% y espina bífida 70%) en el estado de Nuevo León.…”

Section: Discussionunclassified

Efecto Del Consumo De Harina De Maíz Fortificada Con Acido Fólico Sobre Los Niveles De Folatos Sanguíneos en Mujeres De Edad Fértil

P¹,

S²,

V³

et al. 2011

Rev. chil. nutr.

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INTRODUCCIÓNEn la literatura médica existe evidencia indiscutible que el consumo de ácido fólico en el período periconcepcional previene en 50 y 75% defectos del tubo neural (DTN) por lo que se recomienda aumentar el consumo de alimentos ricos en folatos y/o fortificados (1). El Centro para el Control de las Enfermedades (CDC) de los Estados Unidos con la finalidad de aumentar los valores de folatos en la población, emitió la recomendación que todas las mujeres en edad fértil, sin antecedentes familiares de DTN deben consumir 400 µg (0.4 mg) de ABSTRACT Fortification of foods is now widely used to prevent folate deficiency. Folic acid has been added to corn flour and its efficacy in the prevention of NTD has been proved. The aim of this study was to compare the effect of the intake of fortified corn-flour versus non fortified flour and to folic acid supplement, on blood folate levels in women of childbearing age. Forty-five women were randomized into three groups according to: (A) use of fortified flour (n=18), (B) non-fortified flour (n=17); (C) supplementation with 5 mg of oral folic acid (n=10). All females answer a dietary and anthropometric questionnaire applied once a month during three months. Blood red cell (IE) and plasmatic (P) folate were measured at the beginning and at the end of the study; also the DNA analysis for the 677T mutation was performed. The corn flour was provided to groups A and B during three months, to be consumed as eight tortillas daily. Group C received 5.0 mg tablet of folic acid (Valdecasas®), once per week, during three months. IE and P folate and hematocrito were significantly increased in women from group C (p<0.05). Only plasmatic folic acid levels were significantly increased in women from groups A and B. Genotype distribution was: 15.6% homozygous TT, 42.2% C/C and 42.2% CT. Weekly administration of 5.0 mg of folic acid is an effective way to increase blood folate levels and shows to be more efficient than fortified corn flour.

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Decline of neural tube defects cases after a folic acid campaign in Nuevo León, México

Cited by 58 publications

References 29 publications

Effects and safety of periconceptional folate supplementation for preventing birth defects

Effects and safety of periconceptional folate supplementation for preventing birth defects

MTHFR 677C→T genotype is associated with folate and homocysteine concentrations in a large, population-based, double-blind trial of folic acid supplementation

Efecto Del Consumo De Harina De Maíz Fortificada Con Acido Fólico Sobre Los Niveles De Folatos Sanguíneos en Mujeres De Edad Fértil

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