Decline of umami preference in aged rats

Miura, Hirohito; Ooki, Makoto; Kanemaru, Norikazu; Harada, Shuitsu

doi:10.1016/j.neulet.2014.06.018

Cited by 7 publications

(8 citation statements)

References 28 publications

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“…Furthermore, only the old-aged group preferred the high (0.3 M) concentration of MSG to the low (0.1 M) concentration. Miura et al [15] reported reduced umami preference in aged Sprague-Dawley rats (21–22 months) compared to a young adult group (5–12 weeks). The umami receptor is a heterodimer of taste receptor type 1 member 1 and 3 (T1R1/T1R3), whereas the sweet receptor comprises taste receptor type 1 member 2 and 3 (T1R2/T1R3) [23].…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, it is possible that not only alterations in physiological function but also in consumption experience caused the differences in taste preferences across age groups. On the other hand, two reports investigated the differences in taste preference between two separate groups (Sprague-Dawley rats aged 5–12 weeks and 21–22 months; B6C3F1/J mice aged 10 and 18 weeks), in which the older animals were naïve to the taste stimuli until reaching the experimental age [15, 16]. These studies revealed a significant reduction of umami preference in the older rats [15], and of sucrose preference in the older mice [16].…”

Section: Introductionmentioning

confidence: 99%

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Taste preference changes throughout different life stages in male rats

et al. 2017

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Taste preference, a key component of food choice, changes with aging. However, it remains unclear how this occurs. To determine differences in taste preference between rats in different life stages, we examined the consumption of taste solutions and water using a two-bottle test. Male Sprague-Dawley rats of different ages were used: juvenile (3–6 weeks), young adult (8–11 weeks), adult (17–20 weeks), middle-aged (34–37 weeks), and old-aged (69–72 weeks). The intakes of the high and low concentration solutions presented simultaneously were measured. We observed that the old-aged group had lower preference ratios for 0.3 M sucrose and 0.1 M MSG in comparison with other groups. The preference ratio for 0.03 mM QHCl was higher in the middle-aged group than in the three younger groups and higher in the old-aged group than the juvenile group. The taste preferences for HCl and NaCl did not significantly differ among the age groups. The old-aged group tended to prefer high concentrations of sucrose, QHCl, NaCl, and MSG to low concentrations, indicating age-related decline in taste sensitivity. We also aimed to investigate differences between life stages in the electrophysiological responses of the chorda tympani nerve, one of the peripheral gustatory nerves, to taste stimuli. The electrophysiological recordings showed that aging did not alter the function of the chorda tympani nerve. This study showed that aging induced alterations in taste preference. It is likely that these alterations are a result of functional changes in other peripheral taste nerves, the gastrointestinal system, or the central nervous system.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Taste preference changes throughout different life stages in male rats

et al. 2017

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“…For example, taste preference for umami substances (5 0 -inosine monophosphate and monosodium glutamate) is blunted in older (22 months old) compared with young (2 months old) rats [14]. In fact, umami and salty taste thresholds seem to be affected most in older (60-75 years) vs. younger (19-33 years) adults, when compared with the other modalities [15].…”

Section: Tastementioning

confidence: 96%

The ageing gastrointestinal tract

Soenen

Rayner

Jones

et al. 2016

Current Opinion in Clinical Nutrition and Metabolic Care

185

113

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Alterations in gut function with ageing have particular implications for oesophageal, gastric, and colonic motility. Older individuals are particularly susceptible to malnutrition, postprandial hypotension, dysphagia, constipation, and faecal incontinence. Decrease in the number of nerve cells of the myenteric plexus that impact digestive absorption and the surface area of the small intestine because of degeneration of villi may lead to blunted absorption of nutrients. Impairment of the intestinal immune system as a result of ageing, including the mucosal layer of the gastrointestinal tract, appears to be a significant contributor to the age-related increase in the incidence and severity of infections.

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“…There are no studies performed in rats using the same concentrations of umami stimuli that were used in this study. However, there are two studies in rats that used lower concentrations of umami stimuli and the rats seem to only prefer umami stimuli at lower concentrations compared to mice (Miura, Ooki, Kanemaru, & Harada, 2014;. In the higher concentration of umami stimuli used in the rats, the rats showed a very low preference ratio, similar to the 0.0001 M QHCl used in this study .…”

Section: Experiments 1: Preference Testsmentioning

confidence: 50%

“…Moreover, these results also revealed a species difference between mice and rats in regards to preference for umami stimuli. Mice seem to prefer MSG and MPG more and at higher concentrations than do rats Miura et al, 2014).…”

Section: Chapter 5 Final Summary and Overall Conclusionmentioning

confidence: 83%

Neuroanatomical Maps and Taste Reactivity to Sweet, Umami, and Bitter Taste in the PBN of C57BL/6J Mice

Saputra¹

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Humans can distinguish at least five different taste qualities, sour, salty, bitter, sweet, and umami (the savory taste of certain amino acids). In neuroscience research, behavioral testing is used to measure the ability of rodents (including inbred mice) to discriminate between the different taste qualities. Taste reactivity and two-bottle preference are behavioral tests that are utilized to investigate different aspects of taste. These tests involve either voluntary or forced consumption of taste stimuli, respectively. Either test can be used to infer the preference and palatability of the stimulus consumed by an animal. viii Experiment 2: Taste Reactivity Behavior .

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Decline of umami preference in aged rats

Cited by 7 publications

References 28 publications

Taste preference changes throughout different life stages in male rats

Taste preference changes throughout different life stages in male rats

The ageing gastrointestinal tract

Neuroanatomical Maps and Taste Reactivity to Sweet, Umami, and Bitter Taste in the PBN of C57BL/6J Mice

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