Responding to recent developments in archaeological theory and growing interest in the 'global Middle Ages', an approach to exploring relations between local and global processes in the medieval world is proposed. The World-systems approach, applied by some historians to these kinds of macroparadigms and questions, can expose significant challenges regarding social and economic development at a global scale. However, here it is suggested that the 'assemblage thought' of Deleuze and Guattari, developed by DeLanda, might offer a more productive approach for assessing the multiscalar interactions that defined the lives of communities in the Middle Ages. Here consideration is given to the character of the Middle Ages and its relation to modernity; the implications of the multi-scalar approach are also exemplified using a brief discussion of the Anglo-Italian wool trade in the Late Middle Ages.