Declínio cognitivo subjetivo, comprometimento cognitivo leve e demência - diagnóstico sindrômico: recomendações do Departamento Científico de Neurologia Cognitiva e do Envelhecimento da Academia Brasileira de Neurologia

Smid, Jerusa; Neto, Adalberto Studart; César-Freitas, Karolina Gouveia; Dourado, Marcia Cristina Nascimento; Kochhann, Renata; Barbosa, Breno José Alencar Pires; Schilling, Lucas Porcello; Balthazar, Márcio Luiz Figueredo; Frota, Norberto Anízio Ferreira; Souza, Leonardo Cruz de; Caramelli, Paulo; Bertolucci, Paulo Henrique Ferreira; Chaves, Márcia Lorena Fagundes; Brucki, Sônia Maria Dozzi; Nitrini, Ricardo; Resende, Elisa de Paula França; Vale, Francisco Assis Carvalho

doi:10.1590/1980-5764-dn-2022-s101pt

Cited by 11 publications

(1 citation statement)

References 95 publications

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“…Diseases that affect the functions of human higher nervous activity and are accompanied by severe cognitive impairment account for a significant proportion of diseases recorded in human populations. The number of cases of such diseases has been rapidly increasing in recent years, due to socio-economic cataclysms and the general aging of the population [1,2]. Neuropathology is generally considered as one of the main health problems, which determines the high social significance and relevance of research aimed at elucidating the causes of such diseases, as well as developing systems for preventing and correcting disorders of human brain activity.…”

Section: Introductionmentioning

confidence: 99%

Are Ischemic Stroke and Alzheimer’s Disease Genetically Consecutive Pathologies?

Filippenkov,

Khrunin,

Mozgovoy

et al. 2023

Biomedicines

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Complex diseases that affect the functioning of the central nervous system pose a major problem for modern society. Among these, ischemic stroke (IS) holds a special place as one of the most common causes of disability and mortality worldwide. Furthermore, Alzheimer’s disease (AD) ranks first among neurodegenerative diseases, drastically reducing brain activity and overall life quality and duration. Recent studies have shown that AD and IS share several common risk and pathogenic factors, such as an overlapping genomic architecture and molecular signature. In this review, we will summarize the genomics and RNA biology studies of IS and AD, discussing the interconnected nature of these pathologies. Additionally, we highlight specific genomic points and RNA molecules that can serve as potential tools in predicting the risks of diseases and developing effective therapies in the future.

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Section: Introductionmentioning

confidence: 99%

Are Ischemic Stroke and Alzheimer’s Disease Genetically Consecutive Pathologies?

Filippenkov,

Khrunin,

Mozgovoy

et al. 2023

Biomedicines

View full text Add to dashboard Cite

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Accuracy of the revised Addenbrooke Cognitive Examination (ACE-R) in older adults with low education and mild cognitive impairment: results of a cross-sectional study in two metropolitan areas of Northeast Brazil

Passinho,

Tavares-Júnior,

Sudo

et al. 2024

J. bras. psiquiatr.

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Objective To determine the diagnostic accuracy of the Addenbrooke’s Cognitive Examination (ACE-R) for older adults with low education, without dementia, in two capitals in northeastern Brazil, compared to subjects with MCI. Methods 100 participants were collected from a previous neurological and psychiatric evaluation and were subsequently subjected to the ACE-R. Among them, 18 subjects with amnestic mild cognitive impairment (aMCI), 22 with non-amnestic mild cognitive impairment (naMCI), and 60 healthy controls. Results Optimal ACE-R accuracy yielded excellent values for the comparison between controls and naMCI [Area Under the Curve (AUC) = 0.919)] and controls and aMCI (AUC= 0.921); conversely, very fair accuracy was reported for the comparison between aMCI and naMCI (AUC= 0.578). Conclusions These findings support establishing reliable cutoff scores for cognitive assessment of elderlies with low schooling and cognitive decline, not dementia, taking into consideration ecological and regional variables.

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Assessment of cognitive function in elderly patients with heart failure

Silva,

Sampaio,

Guimarães

et al. 2024

Rev. Assoc. Med. Bras.

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Declínio cognitivo subjetivo, comprometimento cognitivo leve e demência - diagnóstico sindrômico: recomendações do Departamento Científico de Neurologia Cognitiva e do Envelhecimento da Academia Brasileira de Neurologia

Cited by 11 publications

References 95 publications

Are Ischemic Stroke and Alzheimer’s Disease Genetically Consecutive Pathologies?

Are Ischemic Stroke and Alzheimer’s Disease Genetically Consecutive Pathologies?

Accuracy of the revised Addenbrooke Cognitive Examination (ACE-R) in older adults with low education and mild cognitive impairment: results of a cross-sectional study in two metropolitan areas of Northeast Brazil

Assessment of cognitive function in elderly patients with heart failure

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