Decoding mouse behavior to explain single-trial decisions and their relationship with neural activity

Weissenberger, Yves; King, Andrew J.; Dahmen, Johannes C

doi:10.1101/567479

Cited by 3 publications

(1 citation statement)

References 33 publications

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“…Data were obtained from neurons in layers 2/3 (150-250 µm below the surface) and while the animals were awake. A1 was localized using widefield imaging as described previously 77 .…”

Section: Two-photon Calcium Imagingmentioning

confidence: 99%

Subcortical circuits mediate communication between primary sensory cortical areas in mice

et al. 2021

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Integration of information across the senses is critical for perception and is a common property of neurons in the cerebral cortex, where it is thought to arise primarily from corticocortical connections. Much less is known about the role of subcortical circuits in shaping the multisensory properties of cortical neurons. We show that stimulation of the whiskers causes widespread suppression of sound-evoked activity in mouse primary auditory cortex (A1). This suppression depends on the primary somatosensory cortex (S1), and is implemented through a descending circuit that links S1, via the auditory midbrain, with thalamic neurons that project to A1. Furthermore, a direct pathway from S1 has a facilitatory effect on auditory responses in higher-order thalamic nuclei that project to other brain areas. Crossmodal corticofugal projections to the auditory midbrain and thalamus therefore play a pivotal role in integrating multisensory signals and in enabling communication between different sensory cortical areas.

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“…Data were obtained from neurons in layers 2/3 (150-250 µm below the surface) and while the animals were awake. A1 was localized using widefield imaging as described previously 77 .…”

Section: Two-photon Calcium Imagingmentioning

confidence: 99%

Subcortical circuits mediate communication between primary sensory cortical areas in mice

et al. 2021

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Determining Mouse Behavior Based on Brain Neuron Activity Data

Vodeneeva,

Meyerov,

Rodimkov

et al. 2024

Lecture Notes in Computer Science

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Subcortical Circuits Mediate Communication Between Primary Sensory Cortical Areas

Lohse

Dahmen

Bajo

et al. 2020

Preprint

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1To form a coherent representation of the environment, the brain must integrate information across 2 different senses. Such multisensory convergence is widespread at the level of the cortex, where it is 3 thought to arise primarily from corticocortical connections. Much less is known about the role of 4 subcortical circuits in shaping the multisensory properties of cortical neurons. We show that sound-5 evoked activity in the mouse auditory cortex is widely suppressed by whisker stimulation. This 6 suppression depends on the primary somatosensory cortex (S1), but surprisingly is implemented 7 through a circuit linking S1 and the auditory thalamocortical system via the auditory midbrain. We 8 also show that an additional, direct pathway exists from S1 to the medial sector of auditory 9 thalamus, which facilitates auditory responses in neurons that do not project to the auditory 10 cortex. The thalamus thus occupies a pivotal role in integrating multisensory signals by 11 somatosensory top-down control of auditory subcortical processing. 12

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Decoding mouse behavior to explain single-trial decisions and their relationship with neural activity

Cited by 3 publications

References 33 publications

Subcortical circuits mediate communication between primary sensory cortical areas in mice

Subcortical circuits mediate communication between primary sensory cortical areas in mice

Determining Mouse Behavior Based on Brain Neuron Activity Data

Subcortical Circuits Mediate Communication Between Primary Sensory Cortical Areas

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